Vinicius Guzzoni, Samantha Joanne McKee, Emma Jane Verkley, Nicholas James Kesler, Prabhatchandra R. Dube, Apurva Lad, B. Timalsina, Tatiana Sousa Cunha, D. Casarini, S. Haller, David Kennedy, Lauren G. Koch
{"title":"对有氧训练的反应揭示了腺嘌呤饮食诱导的慢性肾脏病模型中心血管适应性的关键差异","authors":"Vinicius Guzzoni, Samantha Joanne McKee, Emma Jane Verkley, Nicholas James Kesler, Prabhatchandra R. Dube, Apurva Lad, B. Timalsina, Tatiana Sousa Cunha, D. Casarini, S. Haller, David Kennedy, Lauren G. Koch","doi":"10.46570/utjms.vol11-2023-950","DOIUrl":null,"url":null,"abstract":"Background: Rat models generated by selective breeding for low (LRT) or high (HRT) response to aerobic training closely embody human phenotypes and can be used to understand the exercise-disease linkages. Aerobic endurance training has been proposed as a model of exercise intervention capable of improving or minimizing the negative consequences of chronic diseases including chronic kidney disease (CKD). Objectives: We hypothesized that resistance to aerobic training induces kidney damage in CKD settings. Methods: Male and Female LRT and HRT rats (~ 17 months of age; n = 30) were freely fed with rodent chow supplemented with","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"85 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Response to aerobic training reveals key differences in cardiovascular adaptation in an adenine diet induced model of chronic kidney disease\",\"authors\":\"Vinicius Guzzoni, Samantha Joanne McKee, Emma Jane Verkley, Nicholas James Kesler, Prabhatchandra R. Dube, Apurva Lad, B. Timalsina, Tatiana Sousa Cunha, D. Casarini, S. Haller, David Kennedy, Lauren G. Koch\",\"doi\":\"10.46570/utjms.vol11-2023-950\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Rat models generated by selective breeding for low (LRT) or high (HRT) response to aerobic training closely embody human phenotypes and can be used to understand the exercise-disease linkages. Aerobic endurance training has been proposed as a model of exercise intervention capable of improving or minimizing the negative consequences of chronic diseases including chronic kidney disease (CKD). Objectives: We hypothesized that resistance to aerobic training induces kidney damage in CKD settings. Methods: Male and Female LRT and HRT rats (~ 17 months of age; n = 30) were freely fed with rodent chow supplemented with\",\"PeriodicalId\":220681,\"journal\":{\"name\":\"Translation: The University of Toledo Journal of Medical Sciences\",\"volume\":\"85 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translation: The University of Toledo Journal of Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46570/utjms.vol11-2023-950\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translation: The University of Toledo Journal of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46570/utjms.vol11-2023-950","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Response to aerobic training reveals key differences in cardiovascular adaptation in an adenine diet induced model of chronic kidney disease
Background: Rat models generated by selective breeding for low (LRT) or high (HRT) response to aerobic training closely embody human phenotypes and can be used to understand the exercise-disease linkages. Aerobic endurance training has been proposed as a model of exercise intervention capable of improving or minimizing the negative consequences of chronic diseases including chronic kidney disease (CKD). Objectives: We hypothesized that resistance to aerobic training induces kidney damage in CKD settings. Methods: Male and Female LRT and HRT rats (~ 17 months of age; n = 30) were freely fed with rodent chow supplemented with
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