通过呼出的冷凝液、问卷和测试获得稳定的慢性阻塞性肺病图像。概念验证研究

Patsiris Stephanos, Afthinos Andreas, Augouste Ligeri, Valsami Katerina, Dimitras Antonis, Exarchos Themistoklis, Vlamos Panagiotis
{"title":"通过呼出的冷凝液、问卷和测试获得稳定的慢性阻塞性肺病图像。概念验证研究","authors":"Patsiris Stephanos, Afthinos Andreas, Augouste Ligeri, Valsami Katerina, Dimitras Antonis, Exarchos Themistoklis, Vlamos Panagiotis","doi":"10.29328/journal.jprr.1001049","DOIUrl":null,"url":null,"abstract":"Background: Changes in lung structures persist in stable Chronic Obstructive Pulmonary Disease (COPD), but their correlation with the clinical picture remains unclear. The purpose of this study was to assess the stable COPD picture via the relationship between exhaled breath condensate (EBC) particle concentration and the Saint George Respiratory Questionnaire (SGRQ), COPD Assessment Test (CAT), and six-minute walking test (6 MWT). Methods: 12 stable COPD and 12 healthy subjects participated in the study. The EBC was collected with Rtube and analyzed using the Accusizer FxNano. Particle concentration was measured and correlated with the findings of the tools used to assess the health status and functional profile of COPD. The results’ analysis was performed with the Spearman’s test and the Mann-Whitney U - test. Results: The COPD group presented a worse picture of health status and functional profile compared to the healthy group. Correlations were observed between components of the SGRQ and CAT. The two groups presented similar levels of EBC particle concentrations, but the number of small particles was higher in COPD subjects. A correlation of the EBC particle concentration with the activity and total score of the SGRQ was only observed in the healthy group. Conclusion: The total particle number was similar in the COPD and healthy groups. A few correlations between the EBC particles and tools used were also observed. The use of EBC particle concentration to monitor COPD status cannot be claimed with confidence because of the small sample size. Further research is necessary, particularly in large-scale groups.","PeriodicalId":477115,"journal":{"name":"Journal of pulmonology and respiratory research","volume":"201 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stable COPD Picture through Exhaled Breath Condensate, Questionnaires and Tests. A Proof of Concept Study\",\"authors\":\"Patsiris Stephanos, Afthinos Andreas, Augouste Ligeri, Valsami Katerina, Dimitras Antonis, Exarchos Themistoklis, Vlamos Panagiotis\",\"doi\":\"10.29328/journal.jprr.1001049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Changes in lung structures persist in stable Chronic Obstructive Pulmonary Disease (COPD), but their correlation with the clinical picture remains unclear. The purpose of this study was to assess the stable COPD picture via the relationship between exhaled breath condensate (EBC) particle concentration and the Saint George Respiratory Questionnaire (SGRQ), COPD Assessment Test (CAT), and six-minute walking test (6 MWT). Methods: 12 stable COPD and 12 healthy subjects participated in the study. The EBC was collected with Rtube and analyzed using the Accusizer FxNano. Particle concentration was measured and correlated with the findings of the tools used to assess the health status and functional profile of COPD. The results’ analysis was performed with the Spearman’s test and the Mann-Whitney U - test. Results: The COPD group presented a worse picture of health status and functional profile compared to the healthy group. Correlations were observed between components of the SGRQ and CAT. The two groups presented similar levels of EBC particle concentrations, but the number of small particles was higher in COPD subjects. A correlation of the EBC particle concentration with the activity and total score of the SGRQ was only observed in the healthy group. Conclusion: The total particle number was similar in the COPD and healthy groups. A few correlations between the EBC particles and tools used were also observed. The use of EBC particle concentration to monitor COPD status cannot be claimed with confidence because of the small sample size. Further research is necessary, particularly in large-scale groups.\",\"PeriodicalId\":477115,\"journal\":{\"name\":\"Journal of pulmonology and respiratory research\",\"volume\":\"201 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pulmonology and respiratory research\",\"FirstCategoryId\":\"0\",\"ListUrlMain\":\"https://doi.org/10.29328/journal.jprr.1001049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pulmonology and respiratory research","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.29328/journal.jprr.1001049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:在慢性阻塞性肺病(COPD)病情稳定期,肺部结构会持续发生变化,但这些变化与临床表现的相关性仍不清楚。本研究旨在通过呼出气体冷凝物(EBC)颗粒浓度与圣乔治呼吸问卷(SGRQ)、慢性阻塞性肺病评估测试(CAT)和六分钟步行测试(6 MWT)之间的关系来评估慢性阻塞性肺病的稳定期症状。方法:12 名病情稳定的慢性阻塞性肺病患者和 12 名健康受试者参加了研究。使用 Rtube 收集 EBC,并使用 Accusizer FxNano 进行分析。测量粒子浓度,并将其与用于评估慢性阻塞性肺病患者健康状况和功能状况的工具的结果相关联。结果分析采用斯皮尔曼检验和曼-惠特尼 U 检验。结果显示与健康组相比,慢性阻塞性肺病组的健康状况和功能状况更差。SGRQ和CAT之间存在相关性。两组的 EBC 颗粒浓度水平相似,但慢性阻塞性肺病受试者的小颗粒数量更多。仅在健康组中观察到 EBC 颗粒浓度与活动和 SGRQ 总分之间存在相关性。结论慢性阻塞性肺病组和健康组的粒子总数相似。还观察到 EBC 颗粒与所用工具之间存在一些相关性。由于样本量较小,因此不能肯定使用 EBC 颗粒浓度来监测慢性阻塞性肺病的状况。有必要开展进一步研究,尤其是在大规模群体中开展研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stable COPD Picture through Exhaled Breath Condensate, Questionnaires and Tests. A Proof of Concept Study
Background: Changes in lung structures persist in stable Chronic Obstructive Pulmonary Disease (COPD), but their correlation with the clinical picture remains unclear. The purpose of this study was to assess the stable COPD picture via the relationship between exhaled breath condensate (EBC) particle concentration and the Saint George Respiratory Questionnaire (SGRQ), COPD Assessment Test (CAT), and six-minute walking test (6 MWT). Methods: 12 stable COPD and 12 healthy subjects participated in the study. The EBC was collected with Rtube and analyzed using the Accusizer FxNano. Particle concentration was measured and correlated with the findings of the tools used to assess the health status and functional profile of COPD. The results’ analysis was performed with the Spearman’s test and the Mann-Whitney U - test. Results: The COPD group presented a worse picture of health status and functional profile compared to the healthy group. Correlations were observed between components of the SGRQ and CAT. The two groups presented similar levels of EBC particle concentrations, but the number of small particles was higher in COPD subjects. A correlation of the EBC particle concentration with the activity and total score of the SGRQ was only observed in the healthy group. Conclusion: The total particle number was similar in the COPD and healthy groups. A few correlations between the EBC particles and tools used were also observed. The use of EBC particle concentration to monitor COPD status cannot be claimed with confidence because of the small sample size. Further research is necessary, particularly in large-scale groups.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信