多学科研究医疗中心医院的生物库为广泛的研究提供了潜力。第二部分.开发所述生物材料库的具体情况和初步成果

Q3 Social Sciences
O. Kopylova, A. Ershova, M. S. Pokrovskaya, A. N. Meshkov, A. I. Borisova, I. Efimova, Z. Z. Serebryanskaya, A. V. Pustelenin, Yu. V. Yuzkov, E. V. Garbuzova, A. M. Velichko, F. R. Sayfutdinov, O. Drapkina
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引用次数: 0

摘要

随着基因研究和其他类型转化医学研究的发展,需要收集大量生物样本和大型数据集。由于对病人的深入检查通常是在住院期间进行的,因此基于电子病历(EMR)数据建立样本库是大有可为的。为此,启动了 "国家治疗和预防医学研究中心医院全面生物样本库 "项目,旨在全面收集住院部病人的血液和相关产品,并建立一个将生物样本、临床和其他类型数据信息结合起来的统一系统。描述 2023 年 8 月 "国家治疗和预防医学研究中心医院全面生物样本库 "项目中生物样本的收集情况,并分析生物样本的描述过程。在国家治疗与预防医学研究中心住院部招募患者,但患者必须签署知情同意书。抽血后,生物材料进入生物库,在生物库中进行样本制备和储存,并将每个生物样本的数据输入专门的 FreezerPRO 系统。与此同时,还利用 EMR 收集病人的临床数据,并将这些数据整合到 Medialog 医疗信息系统中。医疗信息系统与生物样本库之间的数据交换专用软件已经开发完成,该软件将输入 Medialog 医疗信息系统的患者信息与包含生物样本详细信息的 FreezerPro 生物样本管理系统结合在一起。截至 2023 年 8 月 25 日,共收集了 3996 名患者的生物样本,并附有详细的临床摘要。其中包括诊断数据(100% 的患者)、实验室检测数据(100%)、辅助临床数据,特别是心电图(100%)、超声心动图(76.8%)、24 小时 Holter 监测(59.8%)、食管胃十二指肠镜检查(27.3%)等。最常见的疾病是高血压(76.0%)、动脉粥样硬化(69.9%)、冠心病(52.9%)、心律失常(50.6%)和糖尿病(19.2%)。此外,25.0%的患者曾接受过支架植入术。多学科研究医疗中心医院内的全生物库可以快速、高质量地收集生物材料和相关数据。收集到的生物样本具有全面、详细的临床注释。对收集的样本进行了初步分析,结果表明这些样本可用于广泛的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biobanking in the hospital of a multidisciplinary research medical center as a potential for a wide research range. Part II. Specifics and first results of developing a described collection of biomaterial
In connection with the development of genetic and other types of research in translational medicine, collections containing a significant number of biospecimens and large data sets are required. Since in-depth examination of patients is most often carried out during hospitalization, the creation of collections based on electronic medical records (EMR) data is promising. In this regard, the project "Total biobanking in the hospital of the National Medical Research Center for Therapy and Preventive Medicine" was initiated, aimed at total biobanking of blood and related products from patients in inpatient departments and the creation of a unified system that combines information on biosamples, clinical and other types of data.Aim. To describe the collection of biospecimens collected within the project "Total biobanking in the hospital of the National Medical Research Center for Therapy and Preventive Medicine" for August 2023, and to analyze the process of biospecimen description.Material and methods. Recruitment of patients is carried out on the basis of inpatient departments of the National Medical Research Center for Therapy and Preventive Medicine, only if the patient signs informed consent. After blood is taken, the biomaterial enters the biobank, where sample preparation and storage is carried out, as well as data about each biosample is entered into a special FreezerPRO system. At the same time, clinical data about the patient is collected using EMR, which are combined in the Medialog medical information system.Results. A special software for data exchange between the medical information system and the biobank has been developed, which combines information about patients entering the Medialog medical information system and the FreezerPro biospecimen management system, which contains detailed information about biospecimens. As of August 25, 2023, biomaterial from 3996 patients was collected, which was accompanied by a detailed clinical summary. In particular, data is available on diagnoses (for 100% of patients), laboratory test data (100%), paraclinical data, in particular, electrocardiography (100%), echocardiography (76,8%), 24-hour Holter monitoring (59,8%), esophagogastroduodenoscopy (27,3%), etc. The most common diseases were hypertension (76,0%), atherosclerosis (69,9%), coronary artery disease (52,9%), arrhythmias (50,6%), diabetes (19,2%). In addition, 25,0% of patients had prior stenting.Conclusion. Total biobanking within the hospital of a multidisciplinary research medical center allows for the rapid and high-quality collection of biomaterial and related data. A collection of biospecimens with comprehensive and detailed clinical annotations has been collected. A primary analysis of the collection was carried, which showed that it can be used for a wide range of studies.
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来源期刊
Cardiovascular Therapy and Prevention
Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.70
自引率
0.00%
发文量
155
审稿时长
6-12 weeks
期刊介绍: The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.
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