建立生物库对传染病发病率进行血清学监测的可能性

Q3 Social Sciences

Cardiovascular Therapy and Prevention Pub Date : 2023-12-10 DOI:10.15829/1728-8800-2023-3693

O. A. Svitich, V. Zverev, T. Solomay, T. A. Semenenko, A. Nozdracheva, T. P. Gotvyanskaya

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引用次数: 0

摘要

目前，监测传染病发病率、控制和预测流行过程是一个热门的健康问题。分析生物库利用与传染性单核细胞增多症有关的爱泼斯坦-巴氏病毒（EBV）对传染病以及包括癌症在内的体细胞病变进行血清学监测的能力。我们使用酶联免疫吸附试验定量检测各种 EBV 蛋白的特异性抗体，研究了 N. F. Gamaleya 国家流行病学和微生物学中心收集的健康人血清样本（2010 年、2016 年、2019 年、2020 年、2021 年和 2022 年）。利用生物材料样本和生物库信息数据库，首次评估了首都表面健康的成年居民中EB病毒流行过程的强度。检查结果显示，0.8% 的人未感染过 EBV，9.4% 的人慢性感染再次复发。多年来，标记物的检出率没有明显变化。经认证的血清采集可有效用于研究人群免疫、个人感染率、全国人口保护等。

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Possibilities of a biobank for serological monitoring of infectious morbidity

Currently, monitoring infectious morbidity, control and forecasting the epidemic process is a topical health problem.Aim. To analyze the capabilities of the biobank for serological monitoring of infectious diseases using the Epstein- Barr virus (EBV), which is associated with infectious mononucleosis, as well as somatic pathology, including cancer.Material and methods. Using the quantitative enzyme- linked immunosorbent assay for specific antibodies to various EBV proteins, we studied blood serum samples from healthy individuals (2010, 2016, 2019, 2020, 2021 and 2022) from the collection of the N. F. Gamaleya National Center of Epidemiology and Microbiology.Results. For the first time, the intensity of EBV epidemic process among apparently healthy adult residents of the capital was assessed using samples of biological material and a biobank information database. At the time of examination, 0,8% of individuals were not infected with EBV, and 9,4% suffered reactivation of a chronic infection. There were no significant changes in detection rate of markers over the years.Conclusion. Certified collections of blood sera can be effectively used to study population immunity, the prevalence of individual infections, population protection nationwide, etc.

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来源期刊

Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

0.00%

发文量

155

审稿时长

6-12 weeks

期刊介绍： The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.