牛尿对毒死蜱诱导的氧化应激的缓解作用

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-12-11 DOI:10.18311/ti/2023/v30i4/33071

Shelly Sharma, Sukanya Mehra, Pooja Chadha

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引用次数: 0

摘要

本研究计划评估牛尿对毒死蜱（CPF）（一种有机磷农药）在大鼠不同组织中引起的有害影响的缓解作用。确定了 LD50，并选择 LD50 的 1/4 即 38 毫克/千克体重作为处理剂量。给体重为 120±10 克的性成熟大鼠口服选定剂量的杀虫剂和牛尿。24、48 和 72 小时后，使用不同组织中的不同生物标志物进行生化分析。根据现有数据推断，氯化石蜡对抗氧化酶有明显的干扰作用。此外，牛尿减轻了氯化石蜡在不同组织中引起的氧化应激。因此，这项研究强调了使用牛尿作为天然抗氧化剂来源的重要性，这对治疗各种涉及氧化应激的疾病大有裨益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitigating Effect of Cow Urine against Chlorpyrifos Induced Oxidative Stress

The present study was planned to evaluate the mitigating effect of cow urine against the detrimental effects induced by Chlorpyrifos (CPF), an organophosphate pesticide, in different tissues of rat. The LD50 was determined and 1/4th of LD50 i.e., 38mg/ kg b.wt was selected for treatment. Sexually mature rats weighing 120±10 g was orally administered with selected dose and cow urine. After 24, 48 and 72 hours biochemical analysis was done using different biomarkers in different tissues. In light of available data, it was deduced that CPF has propensity to cause marked perturbations in the antioxidant enzymes. Further, cow urine mitigated the oxidative stress induced by CPF in different tissues. Thus, this study emphasizes the importance of use of cow urine as a natural source of antioxidants which could be beneficial in the therapeutic world for the treatment of various disorders implicating oxidative stress.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.