Successful Combination Therapeutic Strategy for Treatment of Digital Necrosis in Systemic Sclerosis

Currently, there are no randomized trials that assess combination treatments of digital ulcers in systemic sclerosis (SSc). Here, we present a clinical case of successful treatment of digital necrosis in SSc patient with diffuse cutaneous involvement with complete recovery for a period of 2 months, using combination therapeutic strategy (felodipine, intravenous iloprost, sildenafil, anticoagulant, local treatment). Treatment of severe digital ischemia in SSc is a challenge in rheumatology. However, complete and quick recovery including in cases with digital necrosis with minimal tissue loss could be achieved with close monitoring of the patients, providing complex care with the use of combination pharmacological therapy and local treatment.