补体成分 C1q 在血管生成中的作用

Mariagiulia Spazzapan, Silvia Pegoraro, C. Agostinis, R. Bulla
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引用次数: 0

摘要

补体成分 C1q 在不同情况下发挥着促进血管生成因子的作用,其作用方式与补体无关。例如,这种分子能够促进螺旋动脉的重塑,以利于生理妊娠,并促进伤口愈合过程。它还参与中风后缺血的血管生成。此外,它还在支持肿瘤血管生长方面发挥作用。鉴于它在生理和病理情况下促进血管生成的作用,还需要其他研究来了解其潜在的治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of complement component C1q in angiogenesis
The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to promote the wound healing process. It is also involved in angiogenesis after post-stroke ischemia. Furthermore, it has a role in supporting the tumor vessel growth. Given its role in promoting angiogenesis both under physiological and pathological situations, other studies are needed to understand its potential therapeutic implications.
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