冠心病和心房颤动患者的血浆氨基酸特异性和心脏代谢风险因素

I. Melnychuk, M. Sharayeva, ,. O. V. Dolynna, O. V. Savchenko, V. Kramarova, V. Lyzogub
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引用次数: 0

摘要

针对小分子代谢物(氨基酸、糖类、核苷酸、脂类)与影响宿主代谢组的肠道微生物群代谢物之间关系的研究,为确定不同疾病的特殊代谢特征提供了可能。众所周知,血浆氨基酸(AA)谱是筛查与肠道菌群失调有关的冠状动脉疾病(CAD)发病机制的一种新的有前途的生物标志物。我们的研究旨在估测心房颤动(AF)的冠心病患者的血浆氨基酸谱,并检查它们与肠道微生物群代谢物之间的联系。300 名患者被分为三组:CAD组--149名患有CAD但无心律失常的患者;CAD+AF组--123名患有CAD并伴有房颤阵发性发作的患者;对照组--28名无CAD和心律失常的患者。采用离子交换液相色谱法检测血浆 AA 水平。结果发现,CAD+房颤患者血浆中谷氨酸、谷氨酰胺、甘氨酸、丙氨酸、缬氨酸和酪氨酸以及异亮氨酸+亮氨酸/缬氨酸、甘氨酸+丝氨酸、甘氨酸/蛋氨酸、苯丙氨酸/酪氨酸、谷氨酰胺/谷氨酸组合的含量发生了显著变化。血浆 AA 谱与肠道微生物群代谢物三甲胺、三甲胺-N-氧化物和粪便短链脂肪酸总量之间存在可靠的联系。研究提出了经过高度验证的血浆 AA 组合异亮氨酸-甘氨酸(ROC 曲线下面积为 0.8122)和苯丙氨酸-甘氨酸(ROC 曲线下面积为 0.8061),可作为 CAD 患者心房颤动阵发性发作的早期标志物。关键词:心房颤动;心脏代谢危险因素;冠心病;肠道微生物群代谢物;血浆氨基酸
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Plasma amino acids pecularities and cardiometabolic risk factors in patients with coronary artery disease and atrial fibrillation
Studies targeting small molecule metabolites (amino acids, sugars, nucleotides, lipids) in connections with gut microbiota metabolites that impact the host metabolome give a possibility to define a special metabolic signature of different diseases. Plasma amino acids (AA) profile is known to be a new promising biomarker for the screening of coronary artery disease (CAD) pathogenesis connected with gut dysbiosis. The aim of our study was to estimate the spectrum of plasma amino acids in CAD patients with atrial fibrillation (AF) and to check their connections with the gut microbiota metabolites. 300 patients were divided into three groups: CAD – 149 patients with CAD but without arrhythmias, CAD+AF – 123 patients with CAD and AF paroxysm and control group– 28 patients without CAD and arrhythmias. Plasma AA level was detected by ion exchange liquid column chromatography. Significant changes in the content of plasma Glutamate, Glutamine, Glycine, Alanine, Valine and Tyrosine and combinations Isoleucine+Leucine/Valine, Glycine+Serine, Glycine/Methionine, Phenylalanine/Tyrosine, Glutamine/Glutamate in CAD+AF patients were detected. A strong reliable connection between plasma AA spectrum and gut microbiota metabolites trimethylamine, trimethylamine-N-oxide and total amount of fecal short chain fatty acids was determined. The highly validated plasma AA combinations Isoleucine – Glycine (area under ROC-curve 0.8122) and Phenylalanine – Glycine (area under ROC-curve 0.8061) that can be used as the early markers of AF paroxysm in CAD patients were proposed. Keywords: atrial fibrillation, cardiometabolic risk factors, coronary artery disease, gut microbiota metabolites, plasma amino acids
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