进行性核上性麻痹、多系统萎缩和皮质基底综合征的平面和容积脑干 MRI 标记。系统回顾与元分析

IF 3.2 Q2 CLINICAL NEUROLOGY
Maria E. Brinia, Ioanna Kapsali, Nikolaos Giagkou, Vasileios Constantinides
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引用次数: 0

摘要

背景:各种磁共振成像标记物--包括中脑和脑桥面积(Marea、Parea)和体积(Mvol、Pvol)、比率(M/Parea、M/Pvol)和复合标记物(磁共振成像帕金森病指标1、2;MRPI 1、2)--已被提出作为理查森综合征(RS)和多系统萎缩-帕金森病(MSA-P)的成像标记物。目前尚未对相关研究进行系统回顾/总体分析,以比较这些成像标志物的诊断准确性。研究方法在Pubmed和Scopus上搜索了超过10名患者(RS、MSA-P或CBS)和超过10名对照组的研究,这些研究均包含Marea、Parea、Mvol、Pvol、M/Parea、M/Pvol、MRPI 1和MRPI 2的数据。结果:共纳入了 25 项关于 RS 的研究、5 项关于 MSA-P 的研究和 4 项关于 CBS 的研究。中脑面积对区分 RS 与对照组的影响最大(Cohen's d = -3.10; p < 0.001),其次是 M/Parea 和 MRPI 1。纳入的研究表现出高度异质性,而发表偏倚较低。结论:中脑面积是 RS 的最佳 MRI 标记,而桥脑面积是 MSA-P 的最佳标记。M/Parea 和 MRPIs 在区分 RS 与对照组方面产生的效应大小较小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Planimetric and Volumetric Brainstem MRI Markers in Progressive Supranuclear Palsy, Multiple System Atrophy, and Corticobasal Syndrome. A Systematic Review and Meta-Analysis
Background: Various MRI markers—including midbrain and pons areas (Marea, Parea) and volumes (Mvol, Pvol), ratios (M/Parea, M/Pvol), and composite markers (magnetic resonance imaging Parkinsonism Indices 1,2; MRPI 1,2)—have been proposed as imaging markers of Richardson’s syndrome (RS) and multiple system atrophy–Parkinsonism (MSA-P). A systematic review/meta-analysis of relevant studies aiming to compare the diagnostic accuracy of these imaging markers is lacking. Methods: Pubmed and Scopus were searched for studies with >10 patients (RS, MSA-P or CBS) and >10 controls with data on Marea, Parea, Mvol, Pvol, M/Parea, M/Pvol, MRPI 1, and MRPI 2. Cohen’s d, as a measure of effect size, was calculated for all markers in RS, MSA-P, and CBS. Results: Twenty-five studies on RS, five studies on MSA-P, and four studies on CBS were included. Midbrain area provided the greatest effect size for differentiating RS from controls (Cohen’s d = −3.10; p < 0.001), followed by M/Parea and MRPI 1. MSA-P had decreased midbrain and pontine areas. Included studies exhibited high heterogeneity, whereas publication bias was low. Conclusions: Midbrain area is the optimal MRI marker for RS, and pons area is optimal for MSA-P. M/Parea and MRPIs produce smaller effect sizes for differentiating RS from controls.
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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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