单中心系统性硬化症患者队列中临床公认的抑郁和心理健康治疗

IF 2.3 Q2 RHEUMATOLOGY
Marissa B. Savoie, Alexandra Poeschla, Na Lu, Yuqing Zhang, M. Bolster, Sara Schoenfeld, F. Castelino
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引用次数: 0

摘要

简介在这项研究中,我们调查了系统性硬化症(SSc)患者的抑郁患病率、抑郁治疗情况和症状负担,并研究了它们与流行病学研究中心抑郁量表修订版(CESD-R)评分之间的关系。研究方法麻省总医院硬皮病前瞻性登记(PRISM)是一项系统性硬化症患者的纵向登记。在 CESD-R 评分≥16,表明可能患有抑郁症的参与者中,我们对他们的精神健康诊断和治疗进行了病历审查。我们使用逻辑回归法研究了人口统计学和临床因素与精神健康诊断或治疗的关系。我们使用量化回归法评估了 SSc 症状和 COVID-19 大流行与 CESD-R 评分之间的关系。结果。在参与 PRISM 的 214 名患者中,129 名参与者(38% 弥漫性和 59% 局限性)至少完成了一份 CESD-R 问卷。在第一次调查中,29% 的人可能患有抑郁症(CESD - R ≥ 16),16% 的人可能患有抑郁症(CESD - R ≥ 23)。在 20 名可能患有抑郁症的参与者中,90% 接受了情绪障碍治疗。在 CESD - R ≥ 16 患者的多变量逻辑回归模型中,所有评估变量(CESD-R 评分、年龄、性别、就业状况、种族和民族)均与精神健康诊断或治疗无关。较高的基线呼吸困难指数、改良罗德南皮肤评分以及加州大学洛杉矶分校硬皮病临床试验联盟胃肠道总分和亚分与较高的 CESD-R 评分相关。结论在这项单中心横断面研究中,16%的参与者有明显的抑郁症状。呼吸困难、皮肤受累程度和胃肠道症状与抑郁症状有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinically Recognized Depression and Mental Health Treatment in a Single Center Cohort of Patients with Systemic Sclerosis
Introduction. In this study, we investigated the prevalence of depression, depression treatment, and symptom burden in patients with systemic sclerosis (SSc) and examined their associations with the center for epidemiologic studies depression scale revised (CESD-R) scores. Methods. The Prospective Registry in Scleroderma at Massachusetts General Hospital (PRISM) is a longitudinal registry of patients with SSc. Among participants with CESD-R score ≥ 16 , indicating possible depression, a chart review was performed for mental health diagnoses and treatments. We examined the relation of demographic and clinical factors to the presence of mental health diagnoses or treatment using logistic regression. We evaluated the association of SSc symptoms and the COVID-19 pandemic with a CESD-R score using quantile regression. Results. Of 214 patients enrolled in PRISM, 129 participants (38% diffuse and 59% limited) completed at least one CESD-R questionnaire. In the first survey, 29% had possible depression ( CESD − R ≥ 16 ) and 16% had probable depression ( CESD − R ≥ 23 ). Of 20 participants with probable depression, 90% received treatment for a mood disorder. In a multivariable logistic regression model among participants with CESD − R ≥ 16 , none of the evaluated variables (CESD-R score, age, gender, employment status, race, and ethnicity) was associated with mental health diagnosis or treatment. Higher baseline dyspnea index, modified Rodnan skin score, and the University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal total score and subscores were associated with higher CESD-R score. Conclusion. In this single-center cross-sectional study, 16% of participants had significant depressive symptoms. Dyspnea, extent of skin involvement, and gastrointestinal symptoms were associated with depression symptoms.
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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