吡啶、异噁唑、噻唑和吲哚衍生物的合成路线和药理作用概述

IF 2.6 3区化学 Q2 CHEMISTRY, ORGANIC

Polycyclic Aromatic Compounds Pub Date : 2024-11-25 DOI:10.1080/10406638.2023.2294768

Pallavi H. M. , Zabiulla , Shaukath Ara Khanum

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引用次数: 0

摘要

杂环化合物是一类具有天然和药理价值的特殊分子，在药物开发中发挥着重要作用。由于90%以上的新药含有杂环化合物，其广泛的药理作用使杂环化合物的研究兴趣迅速增加。氮杂环化合物是抗生素、维生素、激素等重要生物活性化学物质的结构单元，在自然界中比其他类型的杂环系统更为普遍。对文献的分析可能为化学家们提供了一个机会，以开发创新的杂环衍生物及其衍生物，这些衍生物已被证明是改善生物和工业生活质量的有用和安全的试剂。

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An Overview of the Synthetic Routes and Pharmacological Aspects of Pyridine, Isoxazole, Thiazole, and Indole Derivatives

Heterocyclic compounds, which are a privileged class of molecules with both natural and pharmacological value, plays an essential role in drug development. Research interest on heterocycles increasing rapidly due to the extensive pharmacological efficacy as more than 90% of novel drugs contain heterocycles. Nitrogen heterocyclic compounds, which are structural units of essential bioactive chemicals such as antibiotics, vitamins, hormones, etc, are more prevalent in nature than other types of heterocyclic ring systems. This analysis of the literature may provide a chance for chemists to develop innovative derivatives of heterocycles and their derivatives that have been demonstrated to be useful and safe agents in improving biological and industrial life quality.

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来源期刊

Polycyclic Aromatic Compounds 化学-有机化学

CiteScore

3.70

自引率

20.80%

发文量

412

审稿时长

3 months

期刊介绍： The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.