文冠果皮提取物对血脂异常 Sprague-Dawley 大鼠胆固醇和甘油三酯水平的影响

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL
Taufik Saputra, Haidar Satya Naufal, Astika Widy Utomo, N. S. Widyastiti, Muhammad Farhan Kurniawan, Arfianty Nur Azizah
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引用次数: 0

摘要

背景 血脂异常的特征是低密度脂蛋白(LDL)和甘油三酯(TG)水平升高,而高密度脂蛋白(HDL)水平降低。胆碱作为一种抗血脂药物有多种副作用,因此需要一种替代品。果胶是一种天然物质,其作用机制与胆碱类似。芒果皮是果胶的来源之一,含有 10-15% 的果胶。本研究旨在证明文冠果(Mangifera indica L.)果皮提取物对血脂异常 Sprague-Dawley 大鼠低密度脂蛋白、高密度脂蛋白和总胆固醇水平的影响。方法 25 只 Sprague-Dawley 大鼠分为 5 组。前 18 天,所有组均给予高脂饮食,随后 15 天分别给予标准饲料(阴性对照组)、80 毫克/200 克体重的胆碱酯酶(Sequest®)(标准治疗组)和芒果皮提取物(M-90 [90 毫克/天]、M-180 [180 毫克/天] 和 M-360 [360 毫克/天] 组)。使用胆固醇氧化酶-苯胺吡唑酮法分析低密度脂蛋白和高密度脂蛋白水平,使用甘油-3-磷酸-氧化酶-苯酚-氨基比林法分析总胆固醇水平。结果 M-360 组降低了低密度脂蛋白水平(p = 0.015),而标准治疗组提高了高密度脂蛋白水平(p = 0.042)。虽然阴性对照组、标准治疗组和 M-360 组的总胆固醇水平有明显变化(p = 0.042),但各组间低密度脂蛋白、高密度脂蛋白和总胆固醇水平的平均差异无明显差异(分别为 p = 0.245、0.328 和 0.454)。结论 M. indica果皮提取物在 360 毫克/天时可降低低密度脂蛋白和总胆固醇水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats
BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats. METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method. RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively). CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.
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来源期刊
Medical Journal of Indonesia
Medical Journal of Indonesia MEDICINE, GENERAL & INTERNAL-
CiteScore
1.00
自引率
20.00%
发文量
25
审稿时长
24 weeks
期刊介绍: Medical Journal of Indonesia is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures, treatment, or other health issues that is important for the development of health care system are also acceptable. Letters and commentaries of our published articles are welcome.
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