肿瘤诱发的骨软化症。

IF 4.3 4区医学 0 MEDICINE, GENERAL & INTERNAL

Panminerva medica Pub Date : 2024-06-01 Epub Date: 2023-12-21 DOI:10.23736/S0031-0808.23.05047-4

Seiji Fukumoto

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引用次数: 0

摘要

肿瘤诱发的骨软化症是一种副肿瘤综合征，其特征是成纤维细胞生长因子23（FGF23）的过度作用导致的低磷血症。自 20 年前克隆出 FGF23 以来，人们对这种疾病有了更广泛的认识。然而，在治疗该病患者方面仍存在一些困难。在这篇综述中，我们将结合 FGF23 的生理和病理生理学功能来讨论这些临床问题。此外，还提出了治疗肿瘤诱发骨软化症疑似患者的个人建议。

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Tumor-induced osteomalacia.

Tumor-induced osteomalacia is one of paraneoplastic syndromes characterized by hypophosphatemia caused by excessive actions of fibroblast growth factor 23 (FGF23). Since the cloning of FGF23 about 20 years ago, more widespread awareness of this disease has been achieved. However, there still remain several difficulties in the management of patients with this disease. In this review, these clinical problems are discussed together with the physiological and pathophysiological functions of FGF23. Personal proposals in the management of patients with suspected patients with tumor-induced osteomalacia are also presented.

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来源期刊

Panminerva medica 医学-医学：内科

CiteScore

5.00

自引率

2.30%

发文量

199

审稿时长

>12 weeks

期刊介绍： Panminerva Medica publishes scientific papers on internal medicine. Manuscripts may be submitted in the form of editorials, original articles, review articles, case reports, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work. Duties and responsibilities of all the subjects involved in the editorial process are summarized at Publication ethics. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors (ICMJE).