Das Ashokkumar Nathulal, Rabinarayan Acharya, Mukesh B Nariya
{"title":"Atavijambira (Atalantia monophylla DC.) 根和茎的抗炎活性。","authors":"Das Ashokkumar Nathulal, Rabinarayan Acharya, Mukesh B Nariya","doi":"10.4103/ayu.ayu_118_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Atalantia monophylla</i> DC. family Rutaceae, a promising drug, has multifaceted ethnomedicinal claims to treat rheumatism, arthritis, paralysis, cough, skin diseases, etc., In traditional practice, root and stem are administered to treat rheumatism and arthritis, respectively.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the anti-inflammatory activity of the root and stem of <i>A. monophylla</i> against carrageenan-induced acute paw edema in wistar albino rats.</p><p><strong>Materials and methods: </strong>Shade dried root and stem were grinded separately into a fine powder (120#) by the mechanical grinder. Test drugs were prepared in <i>Phanta</i> (hot infusion) form and used as fresh (<i>A. monophylla</i> root <i>Phanta</i> [AMRP] and <i>A. monophylla</i> stem <i>Phanta</i> [AMSP]). Difference between the groups was statistically determined by one-way ANOVA, followed by Dunnett's multiple \"<i>t</i>\" test for unpaired data.</p><p><strong>Results: </strong>AMSP showed a significant decrease in paw inflammation at all-time interval (<i>P</i> < 0.05), whereas AMRP produced nonsignificant decrease in paw inflammation at 1 h (43.53%) and 5 h (25.74%) while significant (<i>P</i> < 0.05) anti-inflammatory activity at 3 h (36.35%) in comparison with the normal control group.</p><p><strong>Conclusion: </strong>The present study concluded that <i>A. monophylla</i> stem is having significant anti-inflammatory activity in comparison to its root when administered in <i>Phanta</i> form against carrageenan-induced acute inflammation in rats.</p>","PeriodicalId":502094,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710230/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anti-inflammatory activity of <i>Atavijambira</i> (<i>Atalantia monophylla</i> DC.) root and stem.\",\"authors\":\"Das Ashokkumar Nathulal, Rabinarayan Acharya, Mukesh B Nariya\",\"doi\":\"10.4103/ayu.ayu_118_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>Atalantia monophylla</i> DC. family Rutaceae, a promising drug, has multifaceted ethnomedicinal claims to treat rheumatism, arthritis, paralysis, cough, skin diseases, etc., In traditional practice, root and stem are administered to treat rheumatism and arthritis, respectively.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the anti-inflammatory activity of the root and stem of <i>A. monophylla</i> against carrageenan-induced acute paw edema in wistar albino rats.</p><p><strong>Materials and methods: </strong>Shade dried root and stem were grinded separately into a fine powder (120#) by the mechanical grinder. Test drugs were prepared in <i>Phanta</i> (hot infusion) form and used as fresh (<i>A. monophylla</i> root <i>Phanta</i> [AMRP] and <i>A. monophylla</i> stem <i>Phanta</i> [AMSP]). Difference between the groups was statistically determined by one-way ANOVA, followed by Dunnett's multiple \\\"<i>t</i>\\\" test for unpaired data.</p><p><strong>Results: </strong>AMSP showed a significant decrease in paw inflammation at all-time interval (<i>P</i> < 0.05), whereas AMRP produced nonsignificant decrease in paw inflammation at 1 h (43.53%) and 5 h (25.74%) while significant (<i>P</i> < 0.05) anti-inflammatory activity at 3 h (36.35%) in comparison with the normal control group.</p><p><strong>Conclusion: </strong>The present study concluded that <i>A. monophylla</i> stem is having significant anti-inflammatory activity in comparison to its root when administered in <i>Phanta</i> form against carrageenan-induced acute inflammation in rats.</p>\",\"PeriodicalId\":502094,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710230/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.ayu_118_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/10/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.ayu_118_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/9 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Anti-inflammatory activity of Atavijambira (Atalantia monophylla DC.) root and stem.
Background: Atalantia monophylla DC. family Rutaceae, a promising drug, has multifaceted ethnomedicinal claims to treat rheumatism, arthritis, paralysis, cough, skin diseases, etc., In traditional practice, root and stem are administered to treat rheumatism and arthritis, respectively.
Aim: The aim of this study was to evaluate the anti-inflammatory activity of the root and stem of A. monophylla against carrageenan-induced acute paw edema in wistar albino rats.
Materials and methods: Shade dried root and stem were grinded separately into a fine powder (120#) by the mechanical grinder. Test drugs were prepared in Phanta (hot infusion) form and used as fresh (A. monophylla root Phanta [AMRP] and A. monophylla stem Phanta [AMSP]). Difference between the groups was statistically determined by one-way ANOVA, followed by Dunnett's multiple "t" test for unpaired data.
Results: AMSP showed a significant decrease in paw inflammation at all-time interval (P < 0.05), whereas AMRP produced nonsignificant decrease in paw inflammation at 1 h (43.53%) and 5 h (25.74%) while significant (P < 0.05) anti-inflammatory activity at 3 h (36.35%) in comparison with the normal control group.
Conclusion: The present study concluded that A. monophylla stem is having significant anti-inflammatory activity in comparison to its root when administered in Phanta form against carrageenan-induced acute inflammation in rats.
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