胃食管反流病的新型治疗方法

IF 1.2 4区 医学 Q3 SURGERY
Surgical Innovation Pub Date : 2024-02-01 Epub Date: 2023-12-20 DOI:10.1177/15533506231223913
Patrick F Leahy
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引用次数: 0

摘要

背景:胃食管反流病(GERD/GORD)是一种胃酸反向流入食管的慢性疾病,会导致心脏灼伤和食管癌。胃酸倒流的原因是食管下括约肌(LES)受损。在过去的一个世纪中,胃食管反流已成为当代主要的胃肠道疾病。质子泵抑制剂类药物可有效改善反流症状。在欧洲,患者的调查费用每年高达 1000 亿欧元。在欧洲,每年损失的工作日费用为 1 000 亿欧元。全球的成本是这一数字的 3 倍:拟用于治疗胃食管反流的装置是一个可生物降解的阀门,通过非手术方式放置在食管-胃交界处,以防止胃向食管反流:使用该专利装置进行了 50 次模拟器研究,以阐明在人体模拟器中最稳定的插入和固定方法。模拟器的设计复制了正常人的胃食管解剖结构和特征。在荷兰阿姆斯特丹医疗中心进行了四次符合伦理规定的动物插入实验。在美国新泽西州哈肯萨克大学医院进行了三次尸体实验,以验证模拟器研究的积极成果:结论:模拟器研究和尸体实验的成功结果使治疗胃食管反流病的 NoReflux 装置的设计得以冻结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Therapeutic Method in Gastro-esophageal Reflux Disease.

Background: Gastro-esophageal reflux disease (GERD/GORD) is a chronic condition in which gastric acid flows backwards up into the esophagus, causing heart burn and a higher disposition to esophageal cancer. The reflux is caused by impairment of the lower esophageal sphincter (LES). Over the past century gastro-esophageal reflux has become the principal gastrointestinal condition of our time. The proton pump inhibitor class of drugs is effective in ameliorating the symptoms of reflux. The cost of investigation of patients in Europe is €100 billion per annum. The cost in days lost from work is €100 billion per annum in Europe. The global cost is 3 times this amount.

Methodology: The proposed device for treating gastro-esophageal reflux is a biodegradable valve that is placed non surgically in the esophago-gastric junction to prevent reflux from the stomach to the esophagus.

Experiment results: 50 simulator studies were performed with the patented device to elucidate the most consistent method of insertion and fixation in a human like simulator. The simulator was designed to replicate the normal human gastro-esophageal anatomy and characteristics. Four animal insertions were performed under ethical regulation at Amsterdam Medical Centre, Netherlands. Three cadaveric experiments were performed at Hackensack University Hospital, New Jersey, USA, to verify the positive outcomes of the simulator studies.

Conclusion: Successful outcomes of simulator studies and cadaveric experiments allowed the design freeze of a NoReflux device for treating gastro-esophageal reflux disease.

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来源期刊
Surgical Innovation
Surgical Innovation 医学-外科
CiteScore
2.90
自引率
0.00%
发文量
72
审稿时长
6-12 weeks
期刊介绍: Surgical Innovation (SRI) is a peer-reviewed bi-monthly journal focusing on minimally invasive surgical techniques, new instruments such as laparoscopes and endoscopes, and new technologies. SRI prepares surgeons to think and work in "the operating room of the future" through learning new techniques, understanding and adapting to new technologies, maintaining surgical competencies, and applying surgical outcomes data to their practices. This journal is a member of the Committee on Publication Ethics (COPE).
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