病例报告:前列腺鳞状细胞癌--基于临床病理学和基因组测序的研究。

IF 2.3 4区 医学 Q3 ONCOLOGY
Pathology & Oncology Research Pub Date : 2023-11-28 eCollection Date: 2023-01-01 DOI:10.3389/pore.2023.1611343
Caixin Zhang, Yong Jia, Qingnuan Kong
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引用次数: 0

摘要

鳞状分化型前列腺癌占所有病例的不到1%,通常与雄激素剥夺治疗(ADT)或放射治疗有关。这种疾病具有侵袭性,由于对传统治疗的反应有限,预后较差。然而,其潜在的分子机制和病因尚未完全明了。以前的研究结果表明,鳞状细胞分化可能源于前列腺腺癌(AC),但这一假设还需要进一步验证。本文介绍了一例联合组织学模式的晚期前列腺癌,包括角化性 SCC 和 AC。研究利用全外显子组测序(WES)数据对这两种亚型进行了分析,发现它们之间的驱动基因突变有明显的重叠。这表明这两种亚型具有共同的克隆起源。这些发现强调了前列腺 SCC 个性化临床管理的重要性,特定的分子发现有助于优化治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Case report: Squamous cell carcinoma of the prostate-a clinicopathological and genomic sequencing-based investigation.

Squamous differentiation of prostate cancer, which accounts for less than 1% of all cases, is typically associated with androgen deprivation treatment (ADT) or radiotherapy. This entity is aggressive and exhibits poor prognosis due to limited response to traditional treatment. However, the underlying molecular mechanisms and etiology are not fully understood. Previous findings suggest that squamous cell differentiation may potentially arise from prostate adenocarcinoma (AC), but further validation is required to confirm this hypothesis. This paper presents a case of advanced prostate cancer with a combined histologic pattern, including keratinizing SCC and AC. The study utilized whole-exome sequencing (WES) data to analyze both subtypes and identified a significant overlap in driver gene mutations between them. This suggests that the two components shared a common origin of clones. These findings emphasize the importance of personalized clinical management for prostate SCC, and specific molecular findings can help optimize treatment strategies.

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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
134
审稿时长
4-8 weeks
期刊介绍: Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.
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