Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek
{"title":"细胞色素 P450 和芳胺 N-乙酰转移酶基因多态性与波兰人头颈癌发病率的关系。","authors":"Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek","doi":"10.13075/ijomeh.1896.02070","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.</p><p><strong>Material and methods: </strong>In group of 280 patients with HNC, the occurrence of polymorphic variants in <i>NAT1</i>(rs72554606), <i>NAT2</i>(rs1799930), <i>CYP1A</i>(rs1799814), <i>CYP2D</i>(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.</p><p><strong>Results: </strong>The results indicated an increased risk of HNC in <i>NAT1</i> polymorphisms in the<i> GC</i> genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and <i>NAT2</i> polymorphism in the<i> GA</i> genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the <i>CYP1A</i> polymorphism the <i>GT</i> genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the <i>TT</i> genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of <i>GA-GC</i> polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in <i>NAT2-NAT1</i> genes increases the risk of HNC. Risk-reducing effect in the polymorphism <i>GG-GT</i> (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), <i>GG-TT</i> (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), <i>GA-TT</i> (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), <i>AA-GT</i> (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in <i>NAT2-CYP1A</i> genes. In the <i>CYP2D-CYP1A</i> genes in the polymorphisms <i>CT-CC</i> (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), <i>TT-GG</i> (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), <i>TT-GC</i> (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), <i>TT-CC</i> (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).</p><p><strong>Conclusions: </strong>The<i> CYP1A</i> polymorphism shows a protective association with HNC. On the other hand, <i>NAT2</i>, <i>NAT1</i> polymorphism influence the susceptibility to developing HNC. The coexistence of the <i>NAT2-NAT1</i> genotypes increases the risk of HNC. In contrast,<i> NAT1-CYP1A</i> and <i>CYP1A-CYP2D</i> reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743347/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population.\",\"authors\":\"Monika Gogolewska, Jacek Kabziński, Ireneusz Majsterek\",\"doi\":\"10.13075/ijomeh.1896.02070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.</p><p><strong>Material and methods: </strong>In group of 280 patients with HNC, the occurrence of polymorphic variants in <i>NAT1</i>(rs72554606), <i>NAT2</i>(rs1799930), <i>CYP1A</i>(rs1799814), <i>CYP2D</i>(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.</p><p><strong>Results: </strong>The results indicated an increased risk of HNC in <i>NAT1</i> polymorphisms in the<i> GC</i> genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and <i>NAT2</i> polymorphism in the<i> GA</i> genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the <i>CYP1A</i> polymorphism the <i>GT</i> genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the <i>TT</i> genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of <i>GA-GC</i> polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in <i>NAT2-NAT1</i> genes increases the risk of HNC. Risk-reducing effect in the polymorphism <i>GG-GT</i> (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), <i>GG-TT</i> (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), <i>GA-TT</i> (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), <i>AA-GT</i> (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in <i>NAT2-CYP1A</i> genes. In the <i>CYP2D-CYP1A</i> genes in the polymorphisms <i>CT-CC</i> (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), <i>TT-GG</i> (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), <i>TT-GC</i> (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), <i>TT-CC</i> (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).</p><p><strong>Conclusions: </strong>The<i> CYP1A</i> polymorphism shows a protective association with HNC. On the other hand, <i>NAT2</i>, <i>NAT1</i> polymorphism influence the susceptibility to developing HNC. The coexistence of the <i>NAT2-NAT1</i> genotypes increases the risk of HNC. In contrast,<i> NAT1-CYP1A</i> and <i>CYP1A-CYP2D</i> reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743347/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.13075/ijomeh.1896.02070\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.13075/ijomeh.1896.02070","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population.
Objectives: Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.
Material and methods: In group of 280 patients with HNC, the occurrence of polymorphic variants in NAT1(rs72554606), NAT2(rs1799930), CYP1A(rs1799814), CYP2D(rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.
Results: The results indicated an increased risk of HNC in NAT1 polymorphisms in the GC genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and NAT2 polymorphism in the GA genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the CYP1A polymorphism the GT genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the TT genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of GA-GC polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in NAT2-NAT1 genes increases the risk of HNC. Risk-reducing effect in the polymorphism GG-GT (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), GG-TT (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), GA-TT (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), AA-GT (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in NAT2-CYP1A genes. In the CYP2D-CYP1A genes in the polymorphisms CT-CC (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), TT-GG (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), TT-GC (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), TT-CC (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).
Conclusions: The CYP1A polymorphism shows a protective association with HNC. On the other hand, NAT2, NAT1 polymorphism influence the susceptibility to developing HNC. The coexistence of the NAT2-NAT1 genotypes increases the risk of HNC. In contrast, NAT1-CYP1A and CYP1A-CYP2D reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.
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Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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