Computational Fluid Dynamic Analysis of customised 3D-printed bone scaffolds with different architectures.

Through the recent years, tissue engineering has been proven as a solid substitute of autografts in the stimulation of bone tissue regeneration, through the development of three dimensional (3D) porous matrices, commonly known as scaffolds. In this work, we analysed two scaffold structures with 500μm pore size, by performing computational fluid dynamics simulations, to compare permeability, Wall Shear Stress (WSS), velocity and pressure distributions. Taking into account those parameters the geometry named as "PCL-50" was the best to anticipate showing a superior performance in supporting cell growth due to the improved flow characteristics in the scaffold.Clinical Relevance- Bone defects that require invasive surgical treatment with high risks in terms of success and effectiveness. Bone tissue engineering (BTE) in combination with the use of computational fluid dynamics (CFD) analysis tools aim to assist in designing optimal scaffolds that better promote bone growth and repair. The fluid dynamic characteristics of a porous scaffold plays a vital role in cell viability and cell growth, affecting the osteogenic performance of the scaffold.