Madia Lozupone, Vincenzo Solfrizzi, Rodolfo Sardone, Vittorio Dibello, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Antonio Daniele, Francesco Panza
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引用次数: 0
摘要
虚弱的概念从生理表型转变为生物心理社会表型，扩大了虚弱的研究领域，包括社会和行为领域，不同的虚弱模型之间存在着重要的相互作用。环境暴露--包括体育锻炼、社会心理因素和饮食--可能在虚弱病理生理学中发挥作用。复杂的内在机制涉及遗传学与表观遗传学以及多病与环境因素的渐进互动。在此，我们回顾了有关表观遗传学特征（即全局 DNA 甲基化、DNA 甲基化年龄加速和 microRNAs）与衰弱（被视为衰老的生物标志物）之间关联的可能机制的文献。虚弱可被认为是环境表观遗传因素对生物衰老的影响，由 DNA 甲基化年龄和计时年龄的冲突引起。
The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded the field of frailty, including social and behavioral domains with critical interaction between different frailty models. Environmental exposures - including physical exercise, psychosocial factors and diet - may play a role in the frailty pathophysiology. Complex underlying mechanisms involve the progressive interactions of genetics with epigenetics and of multimorbidity with environmental factors. Here we review the literature on possible mechanisms explaining the association between epigenetic hallmarks (i.e., global DNA methylation, DNA methylation age acceleration and microRNAs) and frailty, considered as biomarkers of aging. Frailty could be considered the result of environmental epigenetic factors on biological aging, caused by conflicting DNA methylation age and chronological age.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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