Shabnam Nohesara, Hamid Mostafavi Abdolmaleky, Sam Thiagalingam, Jin-Rong Zhou
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引用次数: 0
摘要
阿尔茨海默病（AD）和帕金森病（PD）的起源涉及基因突变、表观遗传变化、神经毒素暴露和肠道微生物群失调。肠道微生物群的动态组成及其代谢产物会影响肠道和血脑屏障的完整性，从而导致 AD 和 PD 的发生。本综述探讨了 AD 和 PD 发病机制中的蛋白质错误折叠、聚集和表观遗传学联系。它还强调了肠道渗漏和微生物群-肠-脑轴通过炎症诱导的表观遗传学改变在促进这些疾病中的作用。此外，我们还研究了饮食、益生菌和微生物群移植在通过表观遗传学改变预防和治疗注意力缺失症和注意力缺失性痴呆症方面的潜力，并讨论了与当前挑战和未来考虑相关的问题。这些方法有望将研究成果转化为实际临床应用。
Gut microbiota defined epigenomes of Alzheimer's and Parkinson's diseases reveal novel targets for therapy.
The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The gut microbiota's dynamic composition and its metabolites influence intestinal and blood-brain barrier integrity, contributing to AD and PD development. This review explores protein misfolding, aggregation and epigenetic links in AD and PD pathogenesis. It also highlights the role of a leaky gut and the microbiota-gut-brain axis in promoting these diseases through inflammation-induced epigenetic alterations. In addition, we investigate the potential of diet, probiotics and microbiota transplantation for preventing and treating AD and PD via epigenetic modifications, along with a discussion related to current challenges and future considerations. These approaches offer promise for translating research findings into practical clinical applications.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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