通过表观遗传机制遗传环境诱导的表型变化。

IF 4.8 Q1 GENETICS & HEREDITY
Environmental Epigenetics Pub Date : 2023-11-22 eCollection Date: 2023-01-01 DOI:10.1093/eep/dvad008
Yukiko Tando, Yasuhisa Matsui
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引用次数: 0

摘要

越来越多的证据表明,表观遗传变化通过各种亲代环境因素改变了各种生物后代的表型。环境因素,包括暴露于化学物质、压力和异常营养,通过不同的表观遗传机制影响亲代生殖细胞的表观基因组,如DNA甲基化、组蛋白修饰以及通过代谢物产生的小RNA。目前尚存在的一些问题是环境诱导的生殖细胞表观遗传变化与后代表型改变之间的因果关系,以及异常表观遗传变化如何逃脱生殖细胞重编程的分子基础。在这篇综述中,我们将以动物物种为重点,介绍表型变化通过亲代环境因素以及伴随的表观遗传和代谢变化而产生的代际遗传和跨代遗传的代表性实例。我们还讨论了表观遗传的分子机制及其可能的生物学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inheritance of environment-induced phenotypic changes through epigenetic mechanisms.

Growing evidence suggests that epigenetic changes through various parental environmental factors alter the phenotypes of descendants in various organisms. Environmental factors, including exposure to chemicals, stress and abnormal nutrition, affect the epigenome in parental germ cells by different epigenetic mechanisms, such as DNA methylation, histone modification as well as small RNAs via metabolites. Some current remaining questions are the causal relationship between environment-induced epigenetic changes in germ cells and altered phenotypes of descendants, and the molecular basis of how the abnormal epigenetic changes escape reprogramming in germ cells. In this review, we introduce representative examples of intergenerational and transgenerational inheritance of phenotypic changes through parental environmental factors and the accompanied epigenetic and metabolic changes, with a focus on animal species. We also discuss the molecular mechanisms of epigenomic inheritance and their possible biological significance.

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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
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