开发新的果冻涂层技术(口服果冻涂层)以改善处方药的依从性。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Biological & pharmaceutical bulletin Pub Date : 2024-01-24 Epub Date: 2023-12-16 DOI:10.1248/bpb.b23-00625
Junya Yamashita, Shota Asai, Hiroki Shingaki, Masakane Hayakawa
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引用次数: 0

摘要

片剂是口服药物中最常见的处方剂型。一直以来,人们通过使用小药片、独特形状的药片和糖衣片等方式来提高药片的服药依从性。此外,口腔崩解片(OD 片)、微片式颗粒剂、果冻和薄膜制剂等新制剂技术也使制作更易于摄取的剂型成为可能。我们开发了一种新型口服果冻涂层配方,可用于任何尺寸的片剂,而无需缩小配方的尺寸。研究发现,在片剂表面形成的这种新型果冻层可改善片剂在适量水的作用下的滑爽性,同时确保溶出曲线不发生变化。此外,果冻层还确保了长期储存的稳定性,而不会影响溶出度曲线。虽然还需要进一步研究,但这种包衣技术可以在药片服用后迅速将药片表面变为果冻状,使药片具有与服用果冻一样的滑爽性,更容易通过咽部,从而提高药物的依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve Prescribed Medication Adherence.

Tablets are the most commonly prescribed dosage form for oral drug administration. Historically, improvement of medication adherence of tablets has been facilitated through, for example, the use of smaller tablets, distinctive shaped tablets and sugar-coated tablets. In addition, new formulation technologies such as orally disintegrating tablets (OD tablets), micro tablet-type granules, jellies, and film formulations are making it possible to create more easily ingested dosage forms. We have developed a new oral jelly coating formulation that can be applied to any sized tablet without reducing the size of the formulation. It was found that this new jelly layer formed on the tablet surface improved the tablet's slipperiness with an appropriate amount of water, while ensuring no change in the dissolution profile. In addition, the jelly layer was ensured storage stability over time without affecting the dissolution profile. Although further studies are needed, this coating technology can quickly change the tablet surface to a jelly-like state after the tablet is taken, giving the tablet the same slipperiness as if it were taken in jelly, making it easier to pass through the pharynx, and thus improving medication adherence.

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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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