{"title":"(S)-诺基他敏对社会隔离饲养小鼠的长效抗绝望和抗失神作用","authors":"Rei Yokoyama , Momoko Higuchi , Wataru Tanabe , Shinji Tsukada , Hisato Igarashi , Kaoru Seiriki , Takanobu Nakazawa , Atsushi Kasai , Yukio Ago , Hitoshi Hashimoto","doi":"10.1016/j.jphs.2023.12.005","DOIUrl":null,"url":null,"abstract":"<div><p>Alternatives to ketamine without psychotomimetic properties for the treatment of depression have attracted much attention. Here, we examined the anti-despair and anti-anhedonia effects of the ketamine metabolites (<em>S</em>)-norketamine ((<em>S</em>)-NK), (<em>R</em>)-NK, (<em>2S,6S</em>)-hydroxynorketamine, and (<em>2R,6R</em>)-hydroxynorketamine in a mouse model of depression induced by social isolation. All ketamine metabolites examined had acute (30 min after administration) anti-despair-like effects in the forced swim test, but only (<em>S</em>)-NK showed a long-lasting (1 week) effect. Additionally, only (<em>S</em>)-NK improved reduced motivation both 30 min and 24 h after injection in the female encounter test. These results suggest that (<em>S</em>)-NK has potent and long-lasting antidepressant-like effects.</p></div>","PeriodicalId":16786,"journal":{"name":"Journal of pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1347861323000737/pdfft?md5=1b245c7e64b23f716e19cc9fd46c5ab8&pid=1-s2.0-S1347861323000737-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice\",\"authors\":\"Rei Yokoyama , Momoko Higuchi , Wataru Tanabe , Shinji Tsukada , Hisato Igarashi , Kaoru Seiriki , Takanobu Nakazawa , Atsushi Kasai , Yukio Ago , Hitoshi Hashimoto\",\"doi\":\"10.1016/j.jphs.2023.12.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Alternatives to ketamine without psychotomimetic properties for the treatment of depression have attracted much attention. Here, we examined the anti-despair and anti-anhedonia effects of the ketamine metabolites (<em>S</em>)-norketamine ((<em>S</em>)-NK), (<em>R</em>)-NK, (<em>2S,6S</em>)-hydroxynorketamine, and (<em>2R,6R</em>)-hydroxynorketamine in a mouse model of depression induced by social isolation. All ketamine metabolites examined had acute (30 min after administration) anti-despair-like effects in the forced swim test, but only (<em>S</em>)-NK showed a long-lasting (1 week) effect. Additionally, only (<em>S</em>)-NK improved reduced motivation both 30 min and 24 h after injection in the female encounter test. These results suggest that (<em>S</em>)-NK has potent and long-lasting antidepressant-like effects.</p></div>\",\"PeriodicalId\":16786,\"journal\":{\"name\":\"Journal of pharmacological sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1347861323000737/pdfft?md5=1b245c7e64b23f716e19cc9fd46c5ab8&pid=1-s2.0-S1347861323000737-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pharmacological sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1347861323000737\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1347861323000737","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice
Alternatives to ketamine without psychotomimetic properties for the treatment of depression have attracted much attention. Here, we examined the anti-despair and anti-anhedonia effects of the ketamine metabolites (S)-norketamine ((S)-NK), (R)-NK, (2S,6S)-hydroxynorketamine, and (2R,6R)-hydroxynorketamine in a mouse model of depression induced by social isolation. All ketamine metabolites examined had acute (30 min after administration) anti-despair-like effects in the forced swim test, but only (S)-NK showed a long-lasting (1 week) effect. Additionally, only (S)-NK improved reduced motivation both 30 min and 24 h after injection in the female encounter test. These results suggest that (S)-NK has potent and long-lasting antidepressant-like effects.
期刊介绍：
Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.
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