{"title":"新皮层神经元的适应和爆发可能是由一个快速钾电导控制的。","authors":"N J Berman, P C Bush, R J Douglas","doi":"10.1113/expphysiol.1989.sp003260","DOIUrl":null,"url":null,"abstract":"<p><p>We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.</p>","PeriodicalId":77774,"journal":{"name":"Quarterly journal of experimental physiology (Cambridge, England)","volume":"74 2","pages":"223-6"},"PeriodicalIF":0.0000,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1113/expphysiol.1989.sp003260","citationCount":"10","resultStr":"{\"title\":\"Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance.\",\"authors\":\"N J Berman, P C Bush, R J Douglas\",\"doi\":\"10.1113/expphysiol.1989.sp003260\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.</p>\",\"PeriodicalId\":77774,\"journal\":{\"name\":\"Quarterly journal of experimental physiology (Cambridge, England)\",\"volume\":\"74 2\",\"pages\":\"223-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1113/expphysiol.1989.sp003260\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Quarterly journal of experimental physiology (Cambridge, England)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1113/expphysiol.1989.sp003260\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Quarterly journal of experimental physiology (Cambridge, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1113/expphysiol.1989.sp003260","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance.
We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.
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