虚拟筛选和鉴定针对耐药结核分枝杆菌 β-酮酰-酰基载体蛋白合成酶 I (KasA) 的有前景的治疗化合物

Journal of Biomolecular Structure and Dynamics Pub Date : 2023-12-13 DOI:10.1080/07391102.2023.2293276

Alexander M. Andrianov, Konstantin V. Furs, Anna V. Gonchar, Alena M. Skrahina, Yixin Wang, Liang-Dong Lyu, Alexander V. Tuzikov

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摘要

新的结核分枝杆菌(Mtb)菌株对目前临床用于结核病治疗的关键药物具有耐药性，这大大降低了治疗的可能性。

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Virtual screening and identification of promising therapeutic compounds against drug-resistant Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase I (KasA)

The emergence of new Mycobacterium tuberculosis (Mtb) strains resistant to the key drugs currently used in the clinic for tuberculosis treatment can substantially reduce the probability of therapy ...

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Journal of Biomolecular Structure and Dynamics

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