微波辅助合成具有生物活性的六元 O 型杂环

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Aramita De, Subhankar Sarkar, A. Majee
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引用次数: 0

摘要

自20世纪70年代末以来,微波辐射已被用作化学反应的替代热能来源。最初用于无机化学,1986年发现了它在有机化学中的潜力。利用微波辐射将电磁能转化为热能,频率在0.3-300 GHz之间,是一种有效的加热方法。微波加热方法在工业过程中具有显著的潜力,可以缩短反应时间,提高收率和选择性。它在多肽和有机合成、材料科学、聚合物化学、生化过程和纳米技术等领域都有应用。微波辅助有机合成是一种环境友好、有利于生产具有生物活性的杂环化合物的方法。含氧杂环化合物种类丰富,具有多种生物功能,是开发新药必不可少的物质。微波技术促进了这些化合物的合成,包括具有生物活性的六元o杂环化合物,如吡咯酮、恶唑酮、呋喃酮、氧烷、恶唑烷和二氧烷。通过利用现代有机转化,微波辅助化学提高了合成过程的效率,导致发现更多有益的分子。本文综述了o-杂环化合物的合成和药用性能的最新研究进展,强调了该领域的优势和需求。它指导研究人员,促进微波辅助绿色合成反应,并为形成生物活性杂环提供灵活的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microwave-assisted Synthesis of Bioactive Six-membered O-heterocycles
Microwave radiation has been utilised since the late 1970s as an alternative thermal energy source for chemical reactions. Initially used in inorganic chemistry, its potential for organic chemistry was revealed in 1986. Convertion of electromagnetic energy into heat, with frequencies ranging from 0.3-300 GHz using microwave irradiation, is an efficient heating method. The microwave heating method has significant potential for industrial processes, reducing reaction times and enhancing yields and selectivity. It finds applications in peptide and organic synthesis, materials science, polymer chemistry, biochemical processes, and nanotechnology. Microwave-assisted organic synthesis is environmentally friendly and beneficial for producing bioactive heterocyclic compounds. Oxygen-containing heterocycles are abundant and possess various biological functions, making them essential for developing new drugs. Microwave technology facilitates the synthesis of these compounds, including bioactive six-membered o-heterocycles such as pyrones, oxazolones, furanones, oxetanes, oxazolidinones, and dioxetanes. By utilizing modern organic transformations, microwave-assisted chemistry enhancesthe efficiency of synthetic processes, leading to the discovery of more beneficial molecules. The review provides an up-to-date analysis of the synthesis and medicinal properties of O-heterocycles, emphasizing the strengths and needs of this field. It guides researchers, facilitating microwave-assisted green synthesis reactions and offering a flexible platform for forming bioactive heterocyclic rings.
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来源期刊
Current Microwave Chemistry
Current Microwave Chemistry CHEMISTRY, MULTIDISCIPLINARY-
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