通过贝叶斯推理为监测巴西 COVID-19 流行病选择模型和估计参数

Lucas Martins Inez, Carlos E.R. Dalla, W. B. D. Silva, J. Dutra, José Mir Justino da Costa
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摘要

2019年,一种新型冠状病毒导致了COVID-19疾病病例的爆发,并迅速演变成一场大流行。在巴西,决策延误和缺乏知识导致每日传播和死亡人数惊人地增加。在这种情况下,研究人员使用数学模型来帮助确定在疾病传播中起作用的参数,从而揭示控制措施。然而,文献中存在许多数学模型,每个模型都有特定的参数需要指定,这导致了一个重要的问题,即哪个模型最能代表大流行的行为。为此,本工作旨在应用近似贝叶斯计算方法选择最佳模型并同时估计参数,以解决上述问题。采用的模型为易感-感染-恢复(SIR)、易感-暴露-感染-恢复(SEIR)、易感-感染-恢复-易感(SIRS)和易感-暴露-感染-恢复-易感(SEIRS)。采用近似贝叶斯计算蒙特卡罗测序(ABC-SMC)方法从4个相互竞争的模型中选择代表感染个体数量的模型,并根据巴西3个时期的COVID-19数据估计模型参数。对ABC-SMC算法和所选模型进行了为期两个月的预测试验。将结果与报告的实际感染人数进行比较。在测试的模型中,发现ABC-SMC算法具有很好的性能,因为数据有噪声,模型不能预测所有参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Selection of models and parameter estimation for monitoring the COVID-19 epidemic in Brazil via Bayesian inference
In 2019, a new strain of coronavirus led to an outbreak of disease cases named COVID-19, evolving rapidly into a pandemic. In Brazil, delayed decision making and lack of knowledge have resulted in an alarming increase in daily transmission and deaths. In this context, researchers used mathematical models to assist in determining the parameters that act in the spread of diseases, revealing containment measures. However, numerous mathematical models exist in the literature, each with specific parameters to be specified, leading to an important question about which model best represents the pandemic behavior. In this regard, this work aims to apply the Approximate Bayesian Computation method to select the best model and simultaneously estimate the parameters to resolve the abovementioned issue. The models adopted were susceptible-infected-recovered (SIR), susceptible-exposed-infected-recovered (SEIR), susceptible-infected-recovered-susceptible (SIRS), and susceptible-exposed-infected-recovered-susceptible (SEIRS). Approximate Bayesian Computation Monte Carlo Sequencing (ABC-SMC) was used to select among four competing models to represent the number of infected individuals and to estimate the model parameters based on three periods of Brazil COVID-19 data. A forecasting test was performed to test the ABC-SMC algorithm and the selected models for two months. The result was compared with the actual number of infected that were reported. Among the teste models, it was found that the ABC-SMC algorithm had a promising performance, since the data were noisy and the models could not predict all parameters.
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