槲皮素/抗PD-1抗体联合疗法调节肠道微生物群、影响巨噬细胞免疫力并重塑肝细胞癌肿瘤微环境

IF 3.1 4区生物学 Q2 Immunology and Microbiology

Frontiers in Bioscience-Landmark Pub Date : 2023-12-01 DOI:10.31083/j.fbl2812327

Ruoxia Wu, Jiaqing Xiong, Ting Zhou, Zhen Zhang, Zhen Huang, Sha Tian, Yongli Wang

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引用次数: 0

摘要

目的:免疫检查点抑制剂(ICIs)的使用为肝细胞癌(HCC)的治疗提供了有希望的策略。本研究旨在探讨槲皮素联合抗程序性细胞死亡1 (anti-PD-1)抗体治疗肝癌的作用及机制。方法:应用槲皮素和抗pd -1抗体治疗肝癌原位移植小鼠肿瘤

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Quercetin/Anti-PD-1 Antibody Combination Therapy Regulates the Gut Microbiota, Impacts Macrophage Immunity and Reshapes the Hepatocellular Carcinoma Tumor Microenvironment

Objective : The use of immune checkpoint inhibitors (ICIs) provides promising strategies for hepatocellular carcinoma (HCC) treat-ment. This study aimed to explore impact and underlying mechanism of the combination therapy of quercetin and anti-programmed cell death 1 (anti-PD-1) antibody on HCC. Methods : Orthotopically transplanted HCC tumors in mice were treated with quercetin, anti-PD-1 antibody

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来源期刊

Frontiers in Bioscience-Landmark 生物-生化与分子生物学

CiteScore

3.40

自引率

3.20%

发文量

301

审稿时长

3 months

期刊介绍： FBL is an international peer-reviewed open access journal of biological and medical science. FBL publishes state of the art advances in any discipline in the area of biology and medicine, including biochemistry and molecular biology, parasitology, virology, immunology, epidemiology, microbiology, entomology, botany, agronomy, as well as basic medicine, preventive medicine, bioinformatics and other related topics.