四次甲基羟基富勒烯 C60(ОН)24：优化的制备合成、特性和应用

Q4 Chemistry

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Pub Date : 2023-12-02 DOI:10.29235/1561-8331-2023-59-4-312-317

E. Dikusar, A. Pushkarchuk, T. V. Bezyazychnaya, E. A. Akishina, E. Kasandrovich, A. Soldatov, S. Kuten, S. Stepin, A. Nizovtsev, S. Kilin, V. A. Kulchitsky, V. Potkin

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引用次数: 0

摘要

四二十羟基富勒烯C60(OH)24具有广泛的独特和有用的性质，使其能够成功地应用于国民经济的许多部门。对这种化合物的兴趣是由于其极高的生物潜力，它表现为对恶性肿瘤的增强作用(与顺铂一起使用时)，并作为放射医学中放射性同位素的递送剂。本文提出了一种简便、易于扩展的方法，即在金属铁存在下，用液态溴催化溴化C60(OH)24四廿羟基富勒烯合成和纯化C60(OH)24四廿羟基富勒烯。研究了用离子交换树脂AB-17-8和tokom -100纯化目标产物的技术。

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Tetraeicosahydroxyfullerene C60(ОН)24: optimized preparative synthesis, properties and applica-tions

Tetraeicosahydroxyfullerene C60(OH)24 has a wide range of unique and useful properties that allow it to be successfully used in a number of sectors of the national economy. Interest in this compound is due to its extremely high biological potential, which manifests itself in a potentiating effect against malignant neoplasms (when used together with cisplatin) and as an agent for the delivery of radioactive isotopes in radiation medicine. This paper presents a convenient and easily scalable procedure for the synthesis and purification of C60(OH)24 tetraeicosahydroxyfullerene by catalytic bromination of C60 fullerene in liquid bromine in the presence of metallic iron. The technology of purification of the target product using ion exchange resins AB-17-8 and TOKEM-100 has been developed.

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来源期刊

Proceedings of the National Academy of Sciences of Belarus, Chemical Series Chemistry-Chemistry (miscellaneous)

CiteScore

0.30

自引率

0.00%

发文量