Neda Sadat Ahmadi, H. Samimagham, Mehdi Hassaniazad, Fatemeh Khajavi-Mayvan, MohammadHosein Sheybani-Arani, Ali Salimi Asl, Mitra Kazemi Jahromi
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Comparing the effectiveness of hyperimmune plasma and plasmapheresis in COVID-19 patients
Introduction: In December 2019, the first clinical signs of patients infected with SARS CoV 2 surfaced, then the fatality rate rose daily with no available definitive therapy. Objectives: Considering the necessity for more research into plasma therapy, the urgency of treating patients with a severe disease, and the lack of comparable studies, we compared the effectiveness of hyperimmune plasma and plasmapheresis in COVID-19 patients. Patients and Methods: In this quasi-experimental study, 38 patients with severe COVID-19 were enrolled in two groups of 19 individuals treated with plasmapheresis and hyperimmune plasma after matching for severity. The researcher documented the patient’s information on a checklist submitted for statistical analysis using the SPSS software. Results: Patients comprised 60.53% of men and 39.5% of women. In this study, 60.53% of patients had underlying conditions, including hypertension and diabetes. The mean length of hospitalization for patients in the hyperimmune plasma group was considerably shorter than those in the plasmapheresis group (P<0.05). Conclusion: The average hospitalization time for patients who received hyperimmune plasma was considerably shorter than the plasmapheresis group. As a result, patients are encouraged to utilize this type of plasma at the earliest stages of the condition.
期刊介绍:
The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.