Yi Lily Zhang, Jun J. Mao, Q. Li, Matthew Weitzman, Kevin T. Liou
{"title":"战场针灸治疗癌症幸存者的慢性肌肉骨骼疼痛:一种新型的肿瘤针灸护理模式","authors":"Yi Lily Zhang, Jun J. Mao, Q. Li, Matthew Weitzman, Kevin T. Liou","doi":"10.3389/fpain.2023.1279420","DOIUrl":null,"url":null,"abstract":"Battlefield Acupuncture (BFA), a standardized auricular acupuncture protocol, is widely used for pain in the military but is not well-studied in oncology. This study examined cancer survivors who received BFA for pain.This is a secondary analysis of a randomized trial that compared the effectiveness of BFA and electroacupuncture vs. usual care for chronic musculoskeletal pain in cancer survivors. This study focused on participants randomized to BFA. Participants received 10 weekly treatments. Needles were placed until one of these stop conditions were satisfied: ten needles were administered; pain severity decreased to ≤1 out of 10; patient declined further needling, or vasovagal reaction was observed. Pain severity was assessed using Brief Pain Inventory. Responders were those with ≥30% pain severity reduction. We examined pain location, BFA stop reason, and pain reduction of participants during the first session. We also examined which factors predicted responder status after the first session (week 1) or the full treatment (week 12).Among 143 randomized to BFA, most common pain locations were lower back (30.8%) and knee/leg (18.2%). Of 138 who initiated treatment, 41 (30.0%) received ten needles; 81 (59.1%) achieved pain ≤1; 14 (10.2%) declined further needling; and 1 (0.7%) had vasovagal reaction. BFA reduced pain severity by 2.9 points (95% CI 2.6 to 3.2) after the first session (P < 0.001). After adjusting for baseline pain severity, responders at week 1 were 2.5 times more likely to be responders at week 12, compared to those who were non-responders at week 1 (AOR 2.5, 95% CI 1.02 to 6.11, P = 0.04). Among those who achieved pain ≤1, 74% were responders at week 12, a higher proportion compared to the proportion of responders among those who received ten needles (39.5%), those who declined further needling (50%), and those with vasovagal reaction (0.0%) (P = 0.001). Those with pain in proximal joints had a higher proportion of responders at week 12, compared to those with pain in distal joints (64.2% vs. 20%, P = 0.008).Specific factors may predict the likelihood of achieving meaningful pain reduction from BFA. 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This study examined cancer survivors who received BFA for pain.This is a secondary analysis of a randomized trial that compared the effectiveness of BFA and electroacupuncture vs. usual care for chronic musculoskeletal pain in cancer survivors. This study focused on participants randomized to BFA. Participants received 10 weekly treatments. Needles were placed until one of these stop conditions were satisfied: ten needles were administered; pain severity decreased to ≤1 out of 10; patient declined further needling, or vasovagal reaction was observed. Pain severity was assessed using Brief Pain Inventory. Responders were those with ≥30% pain severity reduction. We examined pain location, BFA stop reason, and pain reduction of participants during the first session. We also examined which factors predicted responder status after the first session (week 1) or the full treatment (week 12).Among 143 randomized to BFA, most common pain locations were lower back (30.8%) and knee/leg (18.2%). Of 138 who initiated treatment, 41 (30.0%) received ten needles; 81 (59.1%) achieved pain ≤1; 14 (10.2%) declined further needling; and 1 (0.7%) had vasovagal reaction. BFA reduced pain severity by 2.9 points (95% CI 2.6 to 3.2) after the first session (P < 0.001). After adjusting for baseline pain severity, responders at week 1 were 2.5 times more likely to be responders at week 12, compared to those who were non-responders at week 1 (AOR 2.5, 95% CI 1.02 to 6.11, P = 0.04). Among those who achieved pain ≤1, 74% were responders at week 12, a higher proportion compared to the proportion of responders among those who received ten needles (39.5%), those who declined further needling (50%), and those with vasovagal reaction (0.0%) (P = 0.001). Those with pain in proximal joints had a higher proportion of responders at week 12, compared to those with pain in distal joints (64.2% vs. 20%, P = 0.008).Specific factors may predict the likelihood of achieving meaningful pain reduction from BFA. 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引用次数: 0
摘要
战地针灸(BFA)是一种标准化的耳穴针灸治疗方案,在军队中广泛用于治疗疼痛,但在肿瘤学中尚未得到充分研究。这项研究调查了接受BFA治疗疼痛的癌症幸存者。这是对一项随机试验的二次分析,该试验比较了BFA和电针治疗癌症幸存者慢性肌肉骨骼疼痛与常规治疗的有效性。这项研究的重点是随机接受BFA治疗的参与者。参与者每周接受10次治疗。直到满足其中一个停止条件:注射10针;疼痛严重程度降至≤1 / 10;患者谢绝进一步针刺,或观察到血管迷走神经反应。使用简短疼痛量表评估疼痛严重程度。缓解者为疼痛严重程度减轻≥30%的患者。我们检查了疼痛部位、BFA停止原因和参与者在第一阶段的疼痛减轻。我们还检查了在第一次治疗(第1周)或完整治疗(第12周)后预测应答状态的因素。在143名随机接受BFA治疗的患者中,最常见的疼痛部位是下背部(30.8%)和膝盖/腿部(18.2%)。在138名开始治疗的患者中,41名(30.0%)接受了10支针头;81例(59.1%)达到疼痛≤1;14家(10.2%)减少了进一步的针刺;1例(0.7%)有血管迷走神经反应。在第一次治疗后,BFA使疼痛严重程度降低了2.9分(95% CI 2.6 - 3.2) (P < 0.001)。调整基线疼痛严重程度后,与第1周无反应者相比,第1周有反应者在第12周有反应者的可能性是无反应者的2.5倍(AOR 2.5, 95% CI 1.02至6.11,P = 0.04)。在疼痛≤1的患者中,74%的患者在第12周有反应,这一比例高于接受10针治疗的患者(39.5%)、不再针刺的患者(50%)和血管迷走神经反应的患者(0.0%)(P = 0.001)。与远端关节疼痛患者相比,近端关节疼痛患者在第12周的应答比例更高(64.2% vs. 20%, P = 0.008)。特定的因素可以预测从BFA中获得有意义的疼痛减轻的可能性。了解这些预测因素可以为精确的疼痛管理和针灸交付模型提供信息。
Battlefield acupuncture for chronic musculoskeletal pain in cancer survivors: a novel care delivery model for oncology acupuncture
Battlefield Acupuncture (BFA), a standardized auricular acupuncture protocol, is widely used for pain in the military but is not well-studied in oncology. This study examined cancer survivors who received BFA for pain.This is a secondary analysis of a randomized trial that compared the effectiveness of BFA and electroacupuncture vs. usual care for chronic musculoskeletal pain in cancer survivors. This study focused on participants randomized to BFA. Participants received 10 weekly treatments. Needles were placed until one of these stop conditions were satisfied: ten needles were administered; pain severity decreased to ≤1 out of 10; patient declined further needling, or vasovagal reaction was observed. Pain severity was assessed using Brief Pain Inventory. Responders were those with ≥30% pain severity reduction. We examined pain location, BFA stop reason, and pain reduction of participants during the first session. We also examined which factors predicted responder status after the first session (week 1) or the full treatment (week 12).Among 143 randomized to BFA, most common pain locations were lower back (30.8%) and knee/leg (18.2%). Of 138 who initiated treatment, 41 (30.0%) received ten needles; 81 (59.1%) achieved pain ≤1; 14 (10.2%) declined further needling; and 1 (0.7%) had vasovagal reaction. BFA reduced pain severity by 2.9 points (95% CI 2.6 to 3.2) after the first session (P < 0.001). After adjusting for baseline pain severity, responders at week 1 were 2.5 times more likely to be responders at week 12, compared to those who were non-responders at week 1 (AOR 2.5, 95% CI 1.02 to 6.11, P = 0.04). Among those who achieved pain ≤1, 74% were responders at week 12, a higher proportion compared to the proportion of responders among those who received ten needles (39.5%), those who declined further needling (50%), and those with vasovagal reaction (0.0%) (P = 0.001). Those with pain in proximal joints had a higher proportion of responders at week 12, compared to those with pain in distal joints (64.2% vs. 20%, P = 0.008).Specific factors may predict the likelihood of achieving meaningful pain reduction from BFA. Understanding these predictors could inform precision pain management and acupuncture delivery models.