利用淀粉纳米颗粒开发抗菌药物

Q3 Materials Science

Current Nanomaterials Pub Date : 2023-12-05 DOI:10.2174/0124054615271640231122034023

Smritilekha Bera

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引用次数: 0

摘要

天然可用的碳水化合物聚合物，淀粉，是可生物降解和生物相容性的，由于存在各种羟基功能，使其适合于药物包封。由于疏水药物的低生物利用度或溶解度导致的剂量相关问题，抗菌药物的多药耐药有时会限制其使用，并造成毒性问题。为了解决这一问题，使用纳米载体递送抗生素，以保护治疗剂免受降解并增强疏水药物的递送。本文综述了淀粉纳米颗粒作为抗菌剂的药物传递载体或载体的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibacterial Drug Development Using Starch Nanoparticles

The naturally available carbohydrate polymer, starch, is biodegradable and biocompatible, making it suitable for drug encapsulation due to the presence of various hydroxy functionalities. Multidrug resistance in antibacterial agents can sometimes limit their use and pose toxicity issues due to dose-related problems resulting from the low bioavailability or solubility of hydrophobic drugs. To address this issue, antibiotics are delivered using nanocarriers that protect therapeutic agents from degradation and enhance the delivery of hydrophobic drugs. This review article discusses the utilization of starch nanoparticles as drug delivery vehicles or carriers for antibacterial agents.

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来源期刊

Current Nanomaterials Materials Science-Materials Science (miscellaneous)

CiteScore

1.60

自引率

0.00%

发文量