[α 1受体阻滞剂哌唑嗪对家兔回肠末端微循环的影响]。

Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR Pub Date : 1989-01-01

B Luther, C Lehmann, A Lewerenz

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引用次数: 0

摘要

用10只家兔观察了特异性α 1受体阻滞剂吡唑嗪对回肠末端微循环的影响。将吡唑嗪注入肠系膜上动脉前后，应用于肠壁的133xe溶液进行同位素清除。由于哌唑嗪降低全身血压的作用，被检查部分的肠道循环减少，尽管预期的肠道血管扩张。α受体阻滞剂对血管源性肠道疾病的治疗适用性仍有疑问。

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[The effect of the alpha1-receptor blocker prazosin on the microcirculation in the terminal ileum of rabbits].

The effect of the specific alpha1-blocker prazosin (Adversuten) on the microcirculation in the region of the terminal ileum was examined on 10 rabbits. Before and after injection of prazosin into the superior mesenteric artery an isotope-clearance of a 133Xe-solution, applied into the intestinal wall, was performed. Because of the systemic blood pressure decreasing effect of prazosin the circulation of the examined part of the intestine was reduced in spite of the intended vasodilation of the intestinal vessels. The therapeutic applicability of alpha-blockers for intestinal diseases of vascular genesis remains questionable.

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Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR

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