一项旨在评估重度抑郁症患者对药物治疗的认识、处方模式、药物不良反应和依从性的观察性研究

Q2 Medicine
U. Parmar, Pranali Puradkar, Kranti Kadam, Firoz M. Tadavi, Snehalata Gajbhiye, Shirish Joshi, Amitoj Sohal
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引用次数: 0

摘要

由于印度国内外关于重度抑郁症(MDD)治疗意识的研究很少,我们决定评估MDD患者的意识,并且由于依从性和意识是相互关联的,我们也评估了依从性。处方模式研究确定由于初始反应差或药物不良反应(adr)而改变处方,这可能导致剂量减少或转换药物和延迟缓解。因此,本研究评估了不良反应模式。经机构伦理委员会批准并征得患者同意后,对200例治疗记录至少3个月的MDD患者进行横断面问卷调查研究。得到的数据在Microsoft Excel中输入,并使用描述性统计进行分析。平均年龄44.65±12.02岁,女性占70%。大多数患者(98%)意识到突然停药的后果,只有12.5%的患者意识到治疗反应的开始。艾司西酞普兰是最常见的抗抑郁药(43.77%),136例不良反应中有67例可归因于艾司西酞普兰。虚弱和疲劳是最常见的不良反应。大多数不良反应(97例)可能与抗抑郁药有关,65%的患者表现出最佳的药物依从性。这项研究揭示了印度重度抑郁症患者的治疗意识和依从性,并强调了对患者进行治疗反应教育的必要性。它还强调了监测不良反应和相应调整处方模式以改善治疗结果的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An observational study to evaluate the awareness of drug treatment, prescription pattern, adverse drug reactions, and adherence in patients of major depressive disorder
Due to the paucity of studies in and out of India that dealt with treatment awareness of major depressive disorder (MDD), we decided to assess the awareness of MDD patients, and since adherence and awareness are linked to each other, we assessed adherence too. Prescription pattern studies identify changes in prescriptions due to poor initial response or adverse drug reactions (ADRs), which may result in dose reduction or switching medications and delay remission. Therefore, the study assessed the ADR pattern. A cross-sectional questionnaire-based study was carried out on 200 MDD patients with treatment records for at least 3 months after getting approval from the Institutional Ethics Committee and consent from the patients. The data obtained were entered in Microsoft Excel and analyzed using descriptive statistics. The mean age was 44.65 ± 12.02 years, and females were 70%. Maximum patients (98%) were aware of the consequence of stopping the drugs suddenly, and only 12.5% were aware of the onset of response to treatment. Escitalopram was the most common antidepressant prescribed (43.77%), and 67 ADRs out of 136 were attributable to it. Weakness and fatigue were the most common ADRs. The majority (97) of the ADRs were possibly related to antidepressants, and 65% of patients showed optimal adherence to medications. This study sheds light on the treatment awareness and adherence of MDD patients in India and highlights the need for educating patients about treatment response. It also emphasizes the importance of monitoring ADRs and adjusting prescription patterns accordingly to improve treatment outcomes.
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来源期刊
Perspectives in Clinical Research
Perspectives in Clinical Research Medicine-Medicine (all)
CiteScore
2.90
自引率
0.00%
发文量
41
审稿时长
36 weeks
期刊介绍: This peer review quarterly journal is positioned to build a learning clinical research community in India. This scientific journal will have a broad coverage of topics across clinical research disciplines including clinical research methodology, research ethics, clinical data management, training, data management, biostatistics, regulatory and will include original articles, reviews, news and views, perspectives, and other interesting sections. PICR will offer all clinical research stakeholders in India – academicians, ethics committees, regulators, and industry professionals -a forum for exchange of ideas, information and opinions.
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