二硝酸异山梨酯片剂改性释放多组分复合物的印刷和评估

Q4 Pharmacology, Toxicology and Pharmaceutics

Ankara Universitesi Eczacilik Fakultesi Dergisi Pub Date : 2023-12-08 DOI:10.33483/jfpau.1075143

Dmytro Oliinykov, Andrii Kaplaushenko, Olena Kryvovi̇az, Olena Tozyuk

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引用次数: 0

摘要

目的:通过将球形基质颗粒压制成片剂，优选最佳工艺参数，并对所制片剂进行评价，制备出硝酸异山梨酯多单位剂型。材料与方法:采用不同压片力，将活性基质颗粒与减震辅助颗粒按不同比例混合制成片芯。并与参比制剂进行了溶出度评价。结果与讨论:确定了有效成分与辅助颗粒的最佳配比及最佳压缩参数。所得到的多单位片剂的释放特性与卡迪克缓释片相似。所采用的技术方法可以通过改变活性颗粒的比例来调节片剂的溶出曲线，并具有不同的活性物质释放动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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İZOSORBİD DİNİTRATIN MODİFİYE SALIM YAPAN ÇOK BİRİMLİ BİLEŞİMİNİN TABLET ŞEKLİNDE BASILMASI VE DEĞERLENDİRİLMESİ

Objective: This study was aimed to create a multiple-unit dosage form of isosorbide dinitrate by pressing spherical matrix granules into tablets, selecting the optimal technology parameters and evaluating the obtained tablets. Material and Method: The tablet cores were prepared from mixtures of active matrix granules and shock-absorbing auxiliary granules in various ratios using diverse tabletting forces. The dissolution profiles of the obtained tablet compositions were evaluated in comparison with the reference preparation. Result and Discussion: An optimal ratio of spheroids with the active component with auxiliary granules along with optimal compression parameters were determined. The resulting as multiple-unit tablets exhibited a release profile similar to that of Cardicket Retard. Used technological approach makes it possible to regulate the dissolution profile of tablets by changing the ratio of active granules with different kinetics of the active substance release.

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来源期刊

Ankara Universitesi Eczacilik Fakultesi Dergisi Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.80

自引率

0.00%

发文量