白细胞介素-6:揭示其在肌肉疏松症发病机制中的作用并探索治疗途径

IF 1.1 Q4 PHARMACOLOGY & PHARMACY
Y. Assyov, Iliana Ganeva, Stefan Ikonomov, Iveta Nedeva, Toni Velikov, Z. Kamenov, T. Velikova
{"title":"白细胞介素-6:揭示其在肌肉疏松症发病机制中的作用并探索治疗途径","authors":"Y. Assyov, Iliana Ganeva, Stefan Ikonomov, Iveta Nedeva, Toni Velikov, Z. Kamenov, T. Velikova","doi":"10.3897/pharmacia.70.e115762","DOIUrl":null,"url":null,"abstract":"This review explores the intricate relationship between interleukin-6 (IL-6) and sarcopenia, a prevalent condition characterized by progressive skeletal muscle loss, particularly in aging populations. Emphasizing the rising prevalence and health challenges posed by sarcopenia, the paper delves into the multifunctional roles of IL-6 in immune response, inflammation and inflammaging associated with sarcopenia. Significantly elevated in sarcopenic individuals, IL-6 prompts an exploration of its molecular impact on muscle wasting. The review critically assesses IL-6 as a potential biomarker for sarcopenia diagnosis and prognosis while also examining therapeutic interventions targeting IL-6 signaling pathways, offering a foundation for future research and the development of targeted therapeutic strategies to alleviate the impact of this debilitating condition.","PeriodicalId":20086,"journal":{"name":"Pharmacia","volume":"76 6","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interleukin-6: Unravelling its role in sarcopenia pathogenesis and exploring therapeutic avenues\",\"authors\":\"Y. Assyov, Iliana Ganeva, Stefan Ikonomov, Iveta Nedeva, Toni Velikov, Z. Kamenov, T. Velikova\",\"doi\":\"10.3897/pharmacia.70.e115762\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review explores the intricate relationship between interleukin-6 (IL-6) and sarcopenia, a prevalent condition characterized by progressive skeletal muscle loss, particularly in aging populations. Emphasizing the rising prevalence and health challenges posed by sarcopenia, the paper delves into the multifunctional roles of IL-6 in immune response, inflammation and inflammaging associated with sarcopenia. Significantly elevated in sarcopenic individuals, IL-6 prompts an exploration of its molecular impact on muscle wasting. The review critically assesses IL-6 as a potential biomarker for sarcopenia diagnosis and prognosis while also examining therapeutic interventions targeting IL-6 signaling pathways, offering a foundation for future research and the development of targeted therapeutic strategies to alleviate the impact of this debilitating condition.\",\"PeriodicalId\":20086,\"journal\":{\"name\":\"Pharmacia\",\"volume\":\"76 6\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-12-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3897/pharmacia.70.e115762\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3897/pharmacia.70.e115762","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

这篇综述探讨了白细胞介素-6 (IL-6)和肌肉减少症之间的复杂关系,肌肉减少症是一种以进行性骨骼肌损失为特征的普遍疾病,特别是在老年人中。强调肌少症的患病率上升和健康挑战,本文深入研究了IL-6在免疫反应、炎症和与肌少症相关的炎症中的多功能作用。IL-6在肌肉萎缩个体中显著升高,提示探索其对肌肉萎缩的分子影响。该综述严格评估了IL-6作为肌少症诊断和预后的潜在生物标志物,同时也检查了针对IL-6信号通路的治疗干预措施,为未来的研究和靶向治疗策略的发展提供了基础,以减轻这种衰弱性疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interleukin-6: Unravelling its role in sarcopenia pathogenesis and exploring therapeutic avenues
This review explores the intricate relationship between interleukin-6 (IL-6) and sarcopenia, a prevalent condition characterized by progressive skeletal muscle loss, particularly in aging populations. Emphasizing the rising prevalence and health challenges posed by sarcopenia, the paper delves into the multifunctional roles of IL-6 in immune response, inflammation and inflammaging associated with sarcopenia. Significantly elevated in sarcopenic individuals, IL-6 prompts an exploration of its molecular impact on muscle wasting. The review critically assesses IL-6 as a potential biomarker for sarcopenia diagnosis and prognosis while also examining therapeutic interventions targeting IL-6 signaling pathways, offering a foundation for future research and the development of targeted therapeutic strategies to alleviate the impact of this debilitating condition.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pharmacia
Pharmacia PHARMACOLOGY & PHARMACY-
CiteScore
2.30
自引率
27.30%
发文量
114
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信