İrfan Küçük, Yusuf Yazgan, Idris Yildirim, Tuğba AKBAŞ ŞİMŞEK, Başak Çakır Güney, Musa Salmanoğlu, Mustafa Kaplan
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引用次数: 0
摘要
目的:膜联蛋白A1(AnxA1)是一种抗炎介质。在本研究中，我们旨在评估炎症性肠病(IBDs)患者血清膜联蛋白A1水平是否与IBDs的临床和实验室特征相关。方法:本病例-对照研究纳入67例溃疡性结肠炎(UC)患者(男性47例，女性20例)、53例克罗恩病(CD)患者(男性37例，女性16例)和60例健康对照(男性36例，女性24例)。UC采用Mayo临床评分系统(MCS)，组织活动指数(HAI)采用Truelove和Richards法测定。对CD患者采用克罗恩病活动性指数(CDAI)。采用蒙特利尔分类对ibd进行定位。结果:UC组、CD组和对照组血清AnxA1平均浓度(26.36±17.30 ng/ml vs 22.98±12.74 vs 24.45±12.18 ng/ml, p=0.404)差异无统计学意义。UC患者的MCS、HAI与血清AnxA1值呈负相关(rho=-0.616, p
Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases
ABSTRACT
Objective: Annexin A1(AnxA1) is an anti-inflammatory mediator. In the current study,we aimed to evaluate whether or not serum Annexin A1 levels of inflammatory boweldiseases (IBDs) patients relate to the clinical and laboratory traits of IBDs.
Methods: This case-control study included 67 ulcerative colitis (UC) patients (47 males and 20 females), 53 Crohn’s disease (CD) patients (37 males and 16 females) and 60 healthy controls (36 males and 24 females). The Mayo Clinical scoring system (MCS) was used for UC and the histological activity index (HAI) was determined by Truelove and Richards method. The Crohn's disease activity index (CDAI) was used for CD patients. Montreal classification was used for the localization of IBDs.
Results: The mean serum AnxA1 concentrations were not statistically significant in UC, CD and the control groups (26.36±17.30 ng/ml vs 22.98±12.74 vs 24.45±12.18 ng/ml respectively, p=0.404). The MCS, HAI of UC patients negatively correlated with the serum AnxA1 values (rho=-0.616, p
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