{"title":"袖带胃切除术后短期内内司芬-1 激素水平、人体测量指标与血糖调节之间的关系：横断面研究","authors":"Ayşegül Sivaslıoğlu, Hakan Buluş, Doğan Öztürk, Evrim Kahramanoğlu Aksoy, Zeynep Göktaş","doi":"10.1007/s13410-023-01297-y","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m<sup>2</sup> who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: <i>p</i> = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease (<i>p</i> < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass (<i>p</i> = 0.009, <i>p</i> = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels (<i>p</i> = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.</p>","PeriodicalId":50328,"journal":{"name":"International Journal of Diabetes in Developing Countries","volume":"19 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between nesfatin-1 hormone levels, anthropometric measurements, and glucose regulation shortly after sleeve gastrectomy: A cross-sectional study\",\"authors\":\"Ayşegül Sivaslıoğlu, Hakan Buluş, Doğan Öztürk, Evrim Kahramanoğlu Aksoy, Zeynep Göktaş\",\"doi\":\"10.1007/s13410-023-01297-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m<sup>2</sup> who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: <i>p</i> = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease (<i>p</i> < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass (<i>p</i> = 0.009, <i>p</i> = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels (<i>p</i> = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.</p>\",\"PeriodicalId\":50328,\"journal\":{\"name\":\"International Journal of Diabetes in Developing Countries\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Diabetes in Developing Countries\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13410-023-01297-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Diabetes in Developing Countries","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13410-023-01297-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between nesfatin-1 hormone levels, anthropometric measurements, and glucose regulation shortly after sleeve gastrectomy: A cross-sectional study
Objective
This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy.
Methods
A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m2 who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed.
Results
Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: p = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease (p < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass (p = 0.009, p = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels (p = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements.
Conclusions
This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.
期刊介绍：
International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.
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