区分在 "配体和无铜 "条件下子桥反应底物活化的线性和非线性（合作）机制

IF 1.3 4区化学 Q4 CHEMISTRY, PHYSICAL

Kinetics and Catalysis Pub Date : 2023-12-12 DOI:10.1134/s0023158423060095

E. V. Larina, A. A. Kurokhtina, N. A. Lagoda, A. F. Schmidt

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引用次数: 0

摘要

摘要在 "无配体和无铜 "条件下，通过改变芳基卤化物和竞争底物中常见碱的性质和浓度，对与一对竞争芳基乙炔发生的 Sonogashira 反应的不同选择性进行了比较研究。随着芳基卤化物性质的变化，选择性差异也随之变化，这与芳基卤化物和芳基乙炔根据化学动力学线性机制依次被活化的观点是一致的。在芳基乙炔竞争的情况下，观察到碱的性质和浓度对反应的选择性没有影响，这表明它们的活化步骤实际上是不可逆的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Distinguishing Between Linear and Nonlinear (Cooperative) Mechanisms of Substrate Activation Under “Ligand- and Copper-Free” Conditions of the Sonogashira Reaction

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Distinguishing Between Linear and Nonlinear (Cooperative) Mechanisms of Substrate Activation Under “Ligand- and Copper-Free” Conditions of the Sonogashira Reaction

Abstract

A comparative study was made of the differential selectivity of the Sonogashira reaction with a pair of competing arylacetylenes under “ligand- and copper-free” conditions by varying nature and concentration of aryl halides and bases common to competing substrates. The change in the differential selectivity with varying nature of aryl halides is consistent with the proposal that aryl halide and arylacetylene are activated sequentially according to a mechanism that is linear in terms of chemical kinetics. The observed lack of influence of the nature and concentration of the base on the selectivity of the reaction under competition between arylacetylenes indicates that the step of their activation is virtually irreversible.

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来源期刊

Kinetics and Catalysis 化学-物理化学

CiteScore

2.10

自引率

27.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Kinetics and Catalysis Russian is a periodical that publishes theoretical and experimental works on homogeneous and heterogeneous kinetics and catalysis. Other topics include the mechanism and kinetics of noncatalytic processes in gaseous, liquid, and solid phases, quantum chemical calculations in kinetics and catalysis, methods of studying catalytic processes and catalysts, the chemistry of catalysts and adsorbent surfaces, the structure and physicochemical properties of catalysts, preparation and poisoning of catalysts, macrokinetics, and computer simulations in catalysis. The journal also publishes review articles on contemporary problems in kinetics and catalysis. The journal welcomes manuscripts from all countries in the English or Russian language.