在 DNA 上搜索目标 - 卷绕的影响

arXiv - QuanBio - Subcellular Processes Pub Date : 2023-12-10 DOI:arxiv-2312.05876

Michael A. Lomholt, Ralf Metzler

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引用次数: 0

摘要

通过促进扩散过程，一些蛋白质在 DNA 上找到目标的速度比在三维细胞质中纯粹扩散的速度更快：它们可以松散地与 DNA 结合，并暂时沿着 DNA 滑动，从而在 DNA 分子本身的引导下找到目标。本章用数学方法详细研究了这一过程，重点是DNA卷绕对这一arch过程的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Target search on DNA -- effect of coiling

Some proteins can find their targets on DNA faster than by pure diffusion in the 3-dimensional cytoplasm, through the process of facilitated diffusion: They can loosely bind to DNA and temporarily slide along it, thus being guided by the DNA molecule itself to the target. This chapter examines this process in mathematical detail with a focus on including the effect of DNA coiling on the search process.

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arXiv - QuanBio - Subcellular Processes

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