含磺酰胺分子的艾滋病毒和结核分枝杆菌抑制剂的研究进展

IF 2.8 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemistry Pub Date : 2023-12-07 DOI:10.1155/2023/3601764

Christiana Abimbola Salubi

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引用次数: 0

摘要

关于磺胺类药物对结核分枝杆菌和各种艾滋病毒菌株的疗效，许多研究都取得了重大成果。这篇科学论文概述了十多年来磺胺类药物在抗 HIV-1 和分枝杆菌方面取得的进展，以及针对极度耐药（XDR）和多重耐药菌株的开发情况。综述的研究为磺胺类药物的结构设计和结构-活性关系（SAR）提供了新的见解，这些药物在抗击 HIV、结核分枝杆菌和多重耐药菌株方面有效且毒性较低。

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Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety

Numerous studies have reported significant results regarding the efficacy of sulfonamides against Mycobacterium tuberculosis and various HIV strains. This scientific paper provides an overview of the progress made over a decade of sulfonamides against HIV-1 and mycobacteria and its development against extremely drug-resistant (XDR) and multidrug-resistant strains. The reviewed study offers novel insights into the structural design and structure-activity relationship (SAR) of sulfonamides that are effective and less toxic in combating HIV, Mycobacterium tuberculosis, and multidrug resistance.

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来源期刊

Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

5.90

自引率

3.30%

发文量

345

审稿时长

16 weeks

期刊介绍： Journal of Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry.