曲马多和海洛因滥用对脑电图结构和认知功能的影响

IF 1.5 Q3 PSYCHIATRY
Marwa Y. Badr, Elsayed A. E. Gad, Ahmed A. E. Mubarak, Yasser A. A. El-Heneedy, Ahmed M. Ibrahim, Asmaa A. E. Belal, Fatma A. El Deep
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引用次数: 0

摘要

阿片类药物被定义为刺激阿片类受体的药物,主要用于治疗中度至重度疼痛。它们会引起中枢神经系统(CNS)的不良反应。本研究旨在评估阿片类药物对脑电活动的影响,阿片类药物对认知功能的影响,并证实阿片类药物成瘾者的脑电活动变化与认知功能之间是否存在相关性。本横断面病例-对照研究对80例(曲马多使用障碍40例和海洛因使用障碍40例)和40例年龄/性别匹配的健康对照进行了研究。所有受试者均接受神经精神病学评估、通过患者及其亲属病史评估阿片类药物使用投诉、尿液物质监测、药物滥用筛查试验(DAST)、脑电图(EEG)和蒙特利尔认知评估(MOCA)的认知评估。阿片类药物依赖导致了全球认知功能障碍,具体的认知学科障碍包括视觉概念、视觉运动跟踪、视觉结构技能、语言功能、注意力、记忆和定向。此外,与对照组相比,脑电活动的影响有显著变化。以较低认知评分为依据的认知障碍与脑电图异常变化的比较显示,研究病例组之间存在显著差异。阿片类药物滥用者认知功能受损和脑电图变化显著,脑电活动变化与认知功能受损有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of tramadol and heroin abuse on electroencephalography structure and cognitive functions
Opioids, defined as medicines that stimulate opioid receptors, are primarily used in the treatment of moderate to severe pain. They induce central nervous system (CNS) adverse effects. This study aimed to assess the effect of opioids on brain electrical activity, the effect of opioids on cognitive functions, and corroborate whether there was any correlation between changes in brain electrical activity and cognitive functions that may do in opioid addicts. This cross-sectional case–control study was performed on 80 cases (divided into two groups 40 cases with tramadol use disorders and 40 cases with heroin use disorders) and 40 age-/sex-matched healthy control. All subjects were subordinated to neuropsychiatric evaluation, assessment of opioid use complaint through history from the case and his relatives, substance monitoring in urine, medicine abuse screening test (DAST), electroencephalography (EEG), and cognitive assessment by Montreal Cognitive Assessment (MOCA). Opioid dependence convinced global cognitive function impairment, specific cognitive disciplines impairment that included visual-conceptual, visual-motor tracking, visual-constructional skills, language function, attention, memory, and orientation. Additionally, affection of the brain’s electrical activities with significant changes compared with control. Comparison of cognitive impairment substantiated by lower cognitive scores in relation to abnormal EEG changes among studied case groups revealed significant differences. Opioid abusers had a significant impairment of cognitive functions and EEG changes with a significant correlation between changes in brain electrical activity and impairment of cognitive functions.
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来源期刊
Middle East Current Psychiatry
Middle East Current Psychiatry Medicine-Psychiatry and Mental Health
CiteScore
3.00
自引率
0.00%
发文量
89
审稿时长
9 weeks
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