自闭症谱系障碍的细胞疗法:临床应用的系统回顾

IF 1.5 Q3 PSYCHIATRY
Ayberk Akat, Erdal Karaöz
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引用次数: 1

摘要

自闭症谱系障碍(ASD)是一种神经发育疾病,会影响患者的沟通能力、与他人交往能力和某些行为方式。尽管存在几种可能的治疗方法,但ASD的有效治疗方法尚未确定。近年来,细胞疗法越来越被认为是治疗自闭症谱系障碍的一种潜在治疗方法。作为细胞治疗的一部分,不同类型的细胞产物使用不同的递送方法进行移植,具有调节免疫系统的能力,表现出旁分泌、神经再生、抗炎和抗氧化应激的作用,以及转移健康的线粒体。在这篇系统综述中,我们比较了已完成的治疗ASD的细胞疗法临床试验的结果和发现。共纳入547项研究,其中11项研究因完成细胞治疗临床试验或临床应用并获得定量结果而被纳入本综述。本系统综述了不同类型的细胞治疗策略治疗ASD的临床试验及其潜在的作用机制。本文综述了这一研究领域的局限性和未来的可能性,以及细胞治疗ASD的安全性和有效性。总的来说,证据表明,各种细胞治疗方法可能为ASD患者提供一种新颖有效的治疗选择,尽管需要进一步的研究来充分了解最佳治疗策略和治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell therapies for autism spectrum disorder: a systematic review of clinical applications
Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects patients’ ability to communicate, engage with others, and behave in certain ways. Despite the existence of several therapy possibilities, an effective treatment for ASD has not yet been identified. Cell therapies have been becoming increasingly recognized in recent years as a potential therapeutic approach for the management of ASD. Different types of cellular products are transplanted using different delivery methods as part of cell therapy, which has the ability to regulate the immune system, demonstrate paracrine, neuro-regenerative, anti-inflammatory, and anti-oxidative stress effects, as well as transfer healthy mitochondria. We have compared the results and findings of completed cell therapy clinical trials for the treatment of ASD in this systematic review. A total of 547 studies were identified, in which 11 studies were found to be eligible to be included in this review as they were completed cell therapy clinical trials or clinical applications with quantitative results for the treatment of ASD patients. This systematic review provides an overview of clinical trials conducted with different types of cell therapy strategies for the treatment of ASD and their potential mechanisms of action. The limitations and future possibilities for this field of study, as well as the safety and efficacy of cell treatments in ASD, were reviewed. Overall, the evidence suggests that various cell therapy methods may offer a novel and effective treatment option for individuals with ASD, although further research is needed to fully understand the optimal treatment strategy and therapeutic potential.
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来源期刊
Middle East Current Psychiatry
Middle East Current Psychiatry Medicine-Psychiatry and Mental Health
CiteScore
3.00
自引率
0.00%
发文量
89
审稿时长
9 weeks
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