非阻塞性无精子症患者的葡萄糖和脂质谱

Ponco Birowo, Dimas Tri Prasetyo, Dwi Ari Pujianto, Widi Atmoko, Nur Rasyid
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摘要

与普通人群相比,具有不同睾丸组织病理学模式的非阻塞性无精子症患者睾酮水平低对糖脂代谢调节的影响尚不清楚。本回顾性研究的目的是检查非阻塞性无精子症男性睾丸组织病理学和代谢谱组成部分之间的关系。参与者被分为两组:非阻塞性无精子症男性和阻塞性无精子症男性。非梗阻性无精子症患者行睾丸活检。本研究纳入115例患者:83例(72.2%)为非阻塞性无精子症,32例(27.8%)为阻塞性无精子症。非梗阻性无精子症患者的血糖浓度、糖化血红蛋白水平和血脂水平与梗阻性无精子症患者相似。在非阻塞性无精子症患者亚组分析中,仅支持细胞综合征患者睾酮水平最低(431±238 ng/dL;P=0.039),促卵泡激素最高为23.4±18.2 mIU/mL;P = 0.002)浓度。他们的甘油三酯浓度也最高(163±114 mg/dL;P = 0.001)。有趣的是,仅支持细胞综合征患者的空腹血糖浓度较低(92±11 mg/dL;P<0.001)和糖化血红蛋白水平(5.9±0.8%;P=0.022)比成熟阻滞和低精子发生的组织病理学模式的患者多。综上所述,不同精子发生方式的非阻塞性无精子症患者的糖脂代谢存在明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glucose and lipid profiles in men with non-obstructive azoospermia
The impact of a low testosterone level among men with non-obstructive azoospermia with various testicular histopathological patterns on the regulation of glucose and lipid metabolism is less well known than among the general population. The aim of this retrospective study was to examine the association between testicular histopathology and components of the metabolic profile among men with non-obstructive azoospermia. Participants were divided into two groups: men with non-obstructive azoospermia and men with obstructive azoospermia. Testicular biopsies were performed among those with non-obstructive azoospermia. We included 115 patients in this study: 83 (72.2%) had non-obstructive azoospermia and 32 (27.8%) had obstructive azoospermia. The plasma glucose concentration, glycated hemoglobin level, and lipid profile were similar between patients with non-obstructive azoospermia and those with obstructive azoospermia. Upon subgroup analysis of patients with non-obstructive azoospermia, those with Sertoli-cell-only syndrome had the lowest testosterone (431 ± 238 ng/dL; P=0.039) and highest follicle-stimulating hormone (23.4 ± 18.2 mIU/mL; P=0.002) concentrations. They also had the highest triglyceride concentration (163 ± 114 mg/dL; P=0.001). Interestingly, patients with Sertoli-cell-only syndrome had a lower fasting plasma glucose concentration (92 ± 11 mg/dL; P<0.001) and glycated hemoglobin level (5.9 ± 0.8%; P=0.022) than those with histopathological patterns of maturation arrest and hypospermatogenesis. In conclusion, differences in glucose and lipid metabolism are evident between men with non-obstructive azoospermia with different spermatogenesis patterns.
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