3d打印石墨烯增强PLA骨再生支架的表征

IF 1.3 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Emerging Materials Research Pub Date : 2023-10-04 DOI:10.1680/jemmr.23.00048

Manoharan Karthic, Kunjan Chockalingam, Chandran Vignesh, K Jawaharlal Nagarajan

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引用次数: 0

摘要

在骨科应用中，骨组织工程(BTE)是一种新的骨缺损治疗方法，涉及使用人工支撑结构支架进行骨再生。本工作的目的是利用熔融沉积建模工艺制备不同孔隙形状(圆形、方形和六边形)和不同孔径(1000、1500和2000 μm)的石墨烯增强聚乳酸(PLA/Gr)支架。通过傅里叶变换红外光谱、热重分析、导数热重分析、扫描电镜和能量色散x射线能谱分析三维打印PLA/Gr支架的特性。水接触角测量结果表明，孔径为1000 μm的支架表面亲水(70±2.7°)。力学性能研究表明，具有1000 μm圆形孔的支架抗压强度为18.53±0.90 MPa，与松质骨相近。此外，本研究还检测了支架的体外生物活性、吸水率和生物降解特性。结果表明，3d打印的孔径为1000 μm的圆形孔形态的PLA/Gr支架作为BTE植入物具有很大的潜力。

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Characterization of 3D-printed graphene-reinforced PLA scaffold for bone regeneration

In orthopedic application, bone tissue engineering (BTE) is a novel treatment method for bone defects involving bone regeneration using an artificial supporting structure called scaffold. The aim of this work is to fabricate graphene-reinforced poly(lactic acid) (PLA/Gr) scaffolds with different pore shapes (circular, square and hexagonal) and different pore sizes (1000, 1500 and 2000 μm) using the fused deposition modeling process. The characteristics of the three-dimensionally (3D) printed PLA/Gr scaffolds were analyzed through Fourier transform infrared spectroscopy, thermogravimetric analysis, derivative thermogravimetry, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The water contact angle measurement showed a hydrophilic surface (70 ± 2.7°) for scaffolds with a pore size of 1000 μm. Mechanical property studies showed that the scaffold with circular 1000 μm pores had a compressive strength of 18.53 ± 0.90 MPa, which was similar to the cancellous bone value. In addition, this study involved an examination of the in vitro bioactivity, water uptake and biodegradation characteristics of the scaffolds. The results reveal that the 3D-printed PLA/Gr scaffold featuring a circular pore shape with a pore size of 1000 μm exhibits great potential as an implant for BTE.

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来源期刊

Emerging Materials Research MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

4.50

自引率

9.10%

发文量

期刊介绍： Materials Research is constantly evolving and correlations between process, structure, properties and performance which are application specific require expert understanding at the macro-, micro- and nano-scale. The ability to intelligently manipulate material properties and tailor them for desired applications is of constant interest and challenge within universities, national labs and industry.