{"title":"丝瓜辅助羟基磷灰石三维支架的制备","authors":"Bijayinee Mohapatra, Tapash R Rautray","doi":"20.00011","DOIUrl":null,"url":null,"abstract":"The incidence of bone-related disorders is abruptly increasing worldwide, and the current therapies available are not sufficient to fulfill the growing demands of patients. Porous three-dimensional (3D) structures cast in combination with ceramics and polymers, with an intention to mimic native bone tissues, are gaining importance because of their better physicochemical and biological activities. The purpose of this study is to prepare a porous scaffold using <i>Luffa cylindrica</i> (LC) as a template coated with hydroxyapatite and gelatin. Guar gum (GG) was used as a binder, and hydroxyapatite powder was added to slurry of 10% gelatin and 1% GG in which pieces of LC were dipped followed by sintering at 900°C. The fabricated scaffolds (LC-GG) were analyzed by using different characterization techniques along with evaluation of porosity and water retention ability. The results revealed that the as-formed scaffolds have 70% porosity with more than 90% water retention ability. The degree of spreading of lymphocytes over the scaffold surface was less in comparison with that of the control, which showed the immunocompatibility of the fabricated scaffold. Based on the aforementioned findings, it is assumed that the synthesized porous structures can suitably be used for biomedical applications.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":"83 7","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Facile fabrication of Luffa cylindrica-assisted 3D hydroxyapatite scaffolds\",\"authors\":\"Bijayinee Mohapatra, Tapash R Rautray\",\"doi\":\"20.00011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The incidence of bone-related disorders is abruptly increasing worldwide, and the current therapies available are not sufficient to fulfill the growing demands of patients. Porous three-dimensional (3D) structures cast in combination with ceramics and polymers, with an intention to mimic native bone tissues, are gaining importance because of their better physicochemical and biological activities. The purpose of this study is to prepare a porous scaffold using <i>Luffa cylindrica</i> (LC) as a template coated with hydroxyapatite and gelatin. Guar gum (GG) was used as a binder, and hydroxyapatite powder was added to slurry of 10% gelatin and 1% GG in which pieces of LC were dipped followed by sintering at 900°C. The fabricated scaffolds (LC-GG) were analyzed by using different characterization techniques along with evaluation of porosity and water retention ability. The results revealed that the as-formed scaffolds have 70% porosity with more than 90% water retention ability. The degree of spreading of lymphocytes over the scaffold surface was less in comparison with that of the control, which showed the immunocompatibility of the fabricated scaffold. Based on the aforementioned findings, it is assumed that the synthesized porous structures can suitably be used for biomedical applications.\",\"PeriodicalId\":48847,\"journal\":{\"name\":\"Bioinspired Biomimetic and Nanobiomaterials\",\"volume\":\"83 7\",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2021-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinspired Biomimetic and Nanobiomaterials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/20.00011\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinspired Biomimetic and Nanobiomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/20.00011","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Facile fabrication of Luffa cylindrica-assisted 3D hydroxyapatite scaffolds
The incidence of bone-related disorders is abruptly increasing worldwide, and the current therapies available are not sufficient to fulfill the growing demands of patients. Porous three-dimensional (3D) structures cast in combination with ceramics and polymers, with an intention to mimic native bone tissues, are gaining importance because of their better physicochemical and biological activities. The purpose of this study is to prepare a porous scaffold using Luffa cylindrica (LC) as a template coated with hydroxyapatite and gelatin. Guar gum (GG) was used as a binder, and hydroxyapatite powder was added to slurry of 10% gelatin and 1% GG in which pieces of LC were dipped followed by sintering at 900°C. The fabricated scaffolds (LC-GG) were analyzed by using different characterization techniques along with evaluation of porosity and water retention ability. The results revealed that the as-formed scaffolds have 70% porosity with more than 90% water retention ability. The degree of spreading of lymphocytes over the scaffold surface was less in comparison with that of the control, which showed the immunocompatibility of the fabricated scaffold. Based on the aforementioned findings, it is assumed that the synthesized porous structures can suitably be used for biomedical applications.
期刊介绍:
Bioinspired, biomimetic and nanobiomaterials are emerging as the most promising area of research within the area of biological materials science and engineering. The technological significance of this area is immense for applications as diverse as tissue engineering and drug delivery biosystems to biomimicked sensors and optical devices.
Bioinspired, Biomimetic and Nanobiomaterials provides a unique scholarly forum for discussion and reporting of structure sensitive functional properties of nature inspired materials.