微型化显微镜用于人体微循环中白细胞-内皮相互作用的无创成像

Arutyun Bagramyan, Charles P. Lin
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引用次数: 0

摘要

我们提出了一种用于人类口腔黏膜微循环成像的微型斜背光显微镜(mOBM),实现了白细胞滚动和粘附的实时、无标记的相衬成像,这是白细胞募集的最初步骤,是炎症的标志。细胞运动成像可以提供新的诊断信息(疾病进展的时间过程,对治疗的反应等),而这些信息是使用传统的静态诊断参数(如细胞数量和形态)无法获得的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interactions in human microcirculation
We present a miniature oblique back-illumination microscope (mOBM) for imaging the microcirculation of human oral mucosa, enabling real-time, label-free phase contrast imaging of leukocyte rolling and adhesion, the initial steps in leukocyte recruitment that is a hallmark of inflammation. Imaging cell motion can provide new diagnostic information (time course of disease progression, response to therapy, etc.) that is not available using traditional static diagnostic parameters such as cell number and morphology.
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