Membrane Thickness Sensitivity of Avian Prestin: Implications

Avian prestin is sensitive to membrane thickness as much as mammalian prestin, which undergoes conformational transitions in membrane area and thereby drives length changes of the cylindrical cell body of outer hair cells. The membrane thickness dependence of mammalian prestin stems from changes in hydrophobic profile in conformational states, accompanied by changes in their membrane area. Even though such area changes are not detected for avian prestin, it nonetheless bends hair bundles of avian short hair cells. Here it is suggested that the motile function of avian prestin can be based on conformational transitions involving shearing deformation of the membrane protein, which also leads to membrane thickness sensitivity.