Mohammed Hasosah, Ahmed Al Sarkhy, Khalid AlQuiar, Ibrahim AlMuslami, Najat AlAhmadi, Ali Almehaidib, Adel AlShahrani, Aziz Alanazi, Muhammad Khan, Abrar Aljohani, Saqqar Alanazi, Tariq Alhassan, Ahlam AlNaqeeb, Marwah Hameedaldeen, Sanabil Albalawi, Safa Abdulmenem, Ibrahim Almehaidib, Mansour Qurashi
{"title":"沙特婴幼儿功能性胃肠疾病患病率:一项横断面多中心研究","authors":"Mohammed Hasosah, Ahmed Al Sarkhy, Khalid AlQuiar, Ibrahim AlMuslami, Najat AlAhmadi, Ali Almehaidib, Adel AlShahrani, Aziz Alanazi, Muhammad Khan, Abrar Aljohani, Saqqar Alanazi, Tariq Alhassan, Ahlam AlNaqeeb, Marwah Hameedaldeen, Sanabil Albalawi, Safa Abdulmenem, Ibrahim Almehaidib, Mansour Qurashi","doi":"10.4103/sjg.sjg_259_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Functional gastrointestinal disorders (FGIDs) are common pediatric problems, but their prevalence in Saudi Arabia is unknown. We aimed to assess the prevalence of FGIDs and risk factors among children in six regions of Saudi Arabia.</p><p><strong>Methods: </strong>This was a cross-sectional multicenter study enrolling children aged 0-48 months, attending pediatric clinics. Questionnaires evaluated the clinical history, symptoms, and sociodemographic information. FGIDs were defined according to Rome IV criteria.</p><p><strong>Results: </strong>The study involved 1011 infants and toddlers (mean [standard deviation (SD)] aged, 21.7 [19.4] months; FGIDs and mean [SD] age 17.4 [16.4] months; controls). FGIDs were diagnosed in 483 (47.7%) of all infants and toddlers. The prevalence of FGIDs was significantly higher in children aged 0-12 months than in those aged 13-48 months ( P < 0.001). The most common disorders were functional regurgitation (13.8%) in infants and functional constipation (9.6%) in toddlers. Univariate regression analysis confirmed that the rate of FGIDs was higher in term gestational age infants (odds ratio (OR) 2.7; 95% confidence interval (CI), 1.76-4.17, P < 0.001), in partial breastfeeding (OR 0.58; 95% CI, 0.40-0.84, P = 0.003), in formula feeding (OR 2.25; 95% CI, 1.51-3.35, P < 0.001), and in subjects with no history of food allergy (OR 2.40; 95% CI, 1.58-3.64, P < 0.001).</p><p><strong>Conclusions: </strong>FGIDs are common in Saudi infants and toddlers (47.7%). Regurgitation is most prevalent in infants, and functional constipation is most common in toddlers. Term gestational age infant, partial breastfeeding, formula feeding, and subjects with no history of food allergy are associated with the prevalence of FGIDs.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198919/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study.\",\"authors\":\"Mohammed Hasosah, Ahmed Al Sarkhy, Khalid AlQuiar, Ibrahim AlMuslami, Najat AlAhmadi, Ali Almehaidib, Adel AlShahrani, Aziz Alanazi, Muhammad Khan, Abrar Aljohani, Saqqar Alanazi, Tariq Alhassan, Ahlam AlNaqeeb, Marwah Hameedaldeen, Sanabil Albalawi, Safa Abdulmenem, Ibrahim Almehaidib, Mansour Qurashi\",\"doi\":\"10.4103/sjg.sjg_259_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Functional gastrointestinal disorders (FGIDs) are common pediatric problems, but their prevalence in Saudi Arabia is unknown. We aimed to assess the prevalence of FGIDs and risk factors among children in six regions of Saudi Arabia.</p><p><strong>Methods: </strong>This was a cross-sectional multicenter study enrolling children aged 0-48 months, attending pediatric clinics. Questionnaires evaluated the clinical history, symptoms, and sociodemographic information. FGIDs were defined according to Rome IV criteria.</p><p><strong>Results: </strong>The study involved 1011 infants and toddlers (mean [standard deviation (SD)] aged, 21.7 [19.4] months; FGIDs and mean [SD] age 17.4 [16.4] months; controls). FGIDs were diagnosed in 483 (47.7%) of all infants and toddlers. The prevalence of FGIDs was significantly higher in children aged 0-12 months than in those aged 13-48 months ( P < 0.001). The most common disorders were functional regurgitation (13.8%) in infants and functional constipation (9.6%) in toddlers. Univariate regression analysis confirmed that the rate of FGIDs was higher in term gestational age infants (odds ratio (OR) 2.7; 95% confidence interval (CI), 1.76-4.17, P < 0.001), in partial breastfeeding (OR 0.58; 95% CI, 0.40-0.84, P = 0.003), in formula feeding (OR 2.25; 95% CI, 1.51-3.35, P < 0.001), and in subjects with no history of food allergy (OR 2.40; 95% CI, 1.58-3.64, P < 0.001).</p><p><strong>Conclusions: </strong>FGIDs are common in Saudi infants and toddlers (47.7%). Regurgitation is most prevalent in infants, and functional constipation is most common in toddlers. Term gestational age infant, partial breastfeeding, formula feeding, and subjects with no history of food allergy are associated with the prevalence of FGIDs.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198919/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/sjg.sjg_259_23\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/sjg.sjg_259_23","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
背景:功能性胃肠疾病(fgid)是常见的儿科问题，但其在沙特阿拉伯的患病率尚不清楚。我们的目的是评估沙特阿拉伯六个地区儿童中fgid的患病率和危险因素。方法:这是一项横断面多中心研究，纳入0-48个月的儿童，在儿科诊所就诊。问卷评估了临床病史、症状和社会人口学信息。fgid是根据罗马IV标准定义的。结果:研究纳入1011名婴幼儿(平均[标准差(SD)]年龄21.7[19.4]个月;fgid和平均[SD]年龄17.4[16.4]个月;控制)。483名(47.7%)婴幼儿被诊断出FGIDs。0-12月龄儿童fgid患病率明显高于13-48月龄儿童(P < 0.001)。最常见的疾病是婴儿的功能性反流(13.8%)和幼儿的功能性便秘(9.6%)。单因素回归分析证实，足月胎龄婴儿的fgid发生率更高(优势比(OR) 2.7;95%置信区间(CI)， 1.76-4.17, P < 0.001)，部分母乳喂养(OR 0.58;95% CI, 0.40-0.84, P = 0.003)，在配方喂养中(OR 2.25;95% CI, 1.51-3.35, P < 0.001)，以及无食物过敏史的受试者(OR 2.40;95% ci, 1.58-3.64, p < 0.001)。结论:fgid在沙特婴幼儿中很常见(47.7%)。反流在婴儿中最为普遍，而功能性便秘在幼儿中最为常见。足月胎龄婴儿、部分母乳喂养、配方喂养和无食物过敏史的受试者与fgid的患病率有关。
Prevalence of functional gastrointestinal disorders in Saudi infants and toddlers: A cross-sectional multicenter study.
Background: Functional gastrointestinal disorders (FGIDs) are common pediatric problems, but their prevalence in Saudi Arabia is unknown. We aimed to assess the prevalence of FGIDs and risk factors among children in six regions of Saudi Arabia.
Methods: This was a cross-sectional multicenter study enrolling children aged 0-48 months, attending pediatric clinics. Questionnaires evaluated the clinical history, symptoms, and sociodemographic information. FGIDs were defined according to Rome IV criteria.
Results: The study involved 1011 infants and toddlers (mean [standard deviation (SD)] aged, 21.7 [19.4] months; FGIDs and mean [SD] age 17.4 [16.4] months; controls). FGIDs were diagnosed in 483 (47.7%) of all infants and toddlers. The prevalence of FGIDs was significantly higher in children aged 0-12 months than in those aged 13-48 months ( P < 0.001). The most common disorders were functional regurgitation (13.8%) in infants and functional constipation (9.6%) in toddlers. Univariate regression analysis confirmed that the rate of FGIDs was higher in term gestational age infants (odds ratio (OR) 2.7; 95% confidence interval (CI), 1.76-4.17, P < 0.001), in partial breastfeeding (OR 0.58; 95% CI, 0.40-0.84, P = 0.003), in formula feeding (OR 2.25; 95% CI, 1.51-3.35, P < 0.001), and in subjects with no history of food allergy (OR 2.40; 95% CI, 1.58-3.64, P < 0.001).
Conclusions: FGIDs are common in Saudi infants and toddlers (47.7%). Regurgitation is most prevalent in infants, and functional constipation is most common in toddlers. Term gestational age infant, partial breastfeeding, formula feeding, and subjects with no history of food allergy are associated with the prevalence of FGIDs.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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