骨髓增生异常综合征中 CD34 和 CD117 免疫组化及巨核细胞形态学的诊断价值：一项回顾性病例对照研究。

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY

Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-03-01 Epub Date: 2023-12-06 DOI:10.1097/PAI.0000000000001177

Ying Zhang, Wenhua Li, Yuanchu Liang, Youli Liu, Wenbin Dai

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引用次数: 0

摘要

本研究评估了CD34和CD117免疫组化（IHC）及巨核细胞形态在骨髓增生异常综合征（MDS）中的诊断价值。在这项研究中，大多数病例（91.2%）都观察到了 CD34 阳性的单个细胞（Ⅰ型）和小细胞团（Ⅱ型）。在 24 例（49%）MDS 患者中发现了 II 型 CD34 阳性，阳性率高于急性髓性白血病（AML）或再生障碍性贫血（AA）。在 44 例（89.8%）MDS 中观察到 II 型 CD117 阳性，在 5 例（10.2%）MDS 中观察到 I 型 CD117 阳性。II 型 CD117 阳性比例高于 AML 或 AA。除一个病例外，大多数 MDS 病例的巨核细胞计数正常或增加。虽然 AML 和 AA 的巨核细胞计数主要下降，但大多数 MDS 患者（81.6%）的巨核细胞异常，而 AML 和 AA 几乎没有发现巨核细胞异常。总之，联合检测 CD34 和 CD117 以及观察巨核细胞数量和形态有助于诊断 MDS。

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Diagnostic Value of CD34 and CD117 Immunohistochemistry and Megakaryocyte Morphology in Myelodysplastic Syndromes: A Retrospective Case-control Study.

This study evaluated the diagnostic value of CD34 and CD117 immunohistochemistry(IHC) and megakaryocyte morphology in Myelodysplastic syndromes (MDS). In this study, CD34-positive individual cells (Type I) and small clusters (Type II) were observed in most cases (91.2%). Type II CD34-positive was seen in 24 (49%) MDS cases, and positive percentage was higher than in acute myelogenous leukemia (AML) or aplastic anemia (AA). Type II CD117-positive were observed in 44 (89.8%) MDS cases and Type I were observed in 5 (10.2%) MDS. Type II CD117-positive percentage was higher than in AML or AA. Megakaryocyte counts were normal or increased in most MDS cases except one. Although megakaryocyte counts of AML and AA were predominantly decreased, Most MDS patients (81.6%) had abnormal megakaryocyte, whereas almost none of megakaryocyte abnormality was found in AML and AA. In conclusion, combined detection of CD34 and CD117 and observation of megakaryocyte count and morphology are useful for the diagnosis of MDS.

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.